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Cellosaurus NKI-4 (CVCL_DG47)

[Text version]
Cell line name NKI-4
Synonyms NKI4; NK1-4; NK14; Nederlands Kanker Instituut-4
Accession CVCL_DG47
Resource Identification Initiative To cite this cell line use: NKI-4 (RRID:CVCL_DG47)
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg58Ter (c.172C>T) (p.Pro72Leu, c.215C>T); ClinVar=VCV000376310; Zygosity=Unspecified (PubMed=9354451).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=4549213; DOI=10.1002/ijc.2910140402
Jan E. de Vries, Santoso Cornain, Philip Rumke;
Cytotoxity of non-T versus T-lymphocytes from melanoma patients and healthy donors on short- and long-term cultured melanoma cells.
Int. J. Cancer 14:427-434(1974)

PubMed=1079770; DOI=10.1016/0014-2964(75)90007-9
Romain Vanwijck, Claire Bouillenne, Shirin Malek-Mansour;
Potentiation and arming of lymphocyte mediated immunity by sera from melanoma patients.
Eur. J. Cancer 11:267-276(1975)

PubMed=1101782; DOI=10.1111/j.1749-6632.1975.tb29200.x
Tjwan Hauw The, Harmke A. Huiges, Heimen Schraffordt Koops, Hendrik Bernard Lamberts, Hendrik O. Nieweg;
Surface antigens on cultured malignant melanoma cells as detected by a membrane immunofluorescence method with human sera. Lack of tumor-specific reactions on melanoma lines.
Ann. N. Y. Acad. Sci. 254:528-540(1975)

PubMed=1104492; DOI=10.1002/ijc.2910160612
Santoso Cornain, Jan E. de Vries, John G. Collard, Claudia Vennegoor, Ineke van Wingerden, Philip Rumke;
Antibodies and antigen expression in human melanoma detected by the immune adherence test.
Int. J. Cancer 16:981-997(1975)

PubMed=6090953; DOI=10.1038/311671a0
Rose Ann Padua, Nigel Charles Barrass, Graham Allan Currie;
A novel transforming gene in a human malignant melanoma cell line.
Nature 311:671-673(1984)

PubMed=1697409
Georgia Chenevix-Trench, Nicholas Gordon Martin, Kay Adrian Oswald Ellem;
Gene expression in melanoma cell lines and cultured melanocytes: correlation between levels of c-src-1, c-myc and p53.
Oncogene 5:1187-1193(1990)

PubMed=9354451
Marina Castellano, Pamela M. Pollock, Marilyn K. Walters, Louise E. Sparrow, Louise M. Down, Brian G. Gabrielli, Peter G. Parsons, Nicholas K. Hayward;
CDKN2A/p16 is inactivated in most melanoma cell lines.
Cancer Res. 57:4868-4875(1997)

PubMed=23039341; DOI=10.1186/1476-4598-11-75; PMCID=PMC3554420
Sara A. Byron, David C. Loch, Candice L. Wellens, Andreas Wortmann, Jia-Yi Wu, John Wang, Kenichi Nomoto, Pamela M. Pollock;
Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN status.
Mol. Cancer 11:75.1-75.15(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DG47
Encyclopedic resources Wikidata; Q54930672
Polymorphism and mutation databases Cosmic; 928726
Entry history
Entry creation13-Jul-2016
Last entry update14-Aug-2025
Version number10