ID   NKI-4
AC   CVCL_DG47
SY   NKI4; NK1-4; NK14; Nederlands Kanker Instituut-4
DR   cancercelllines; CVCL_DG47
DR   Cosmic; 928726
DR   Wikidata; Q54930672
RX   PubMed=1079770;
RX   PubMed=1101782;
RX   PubMed=1104492;
RX   PubMed=1697409;
RX   PubMed=4549213;
RX   PubMed=6090953;
RX   PubMed=9354451;
RX   PubMed=23039341;
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg58Ter (c.172C>T) (p.Pro72Leu, c.215C>T); ClinVar=VCV000376310; Zygosity=Unspecified (PubMed=9354451).
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 05-10-23; Version: 8
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RX   PubMed=1079770; DOI=10.1016/0014-2964(75)90007-9;
RA   Vanwijck R., Bouillenne C., Malek-Mansour S.;
RT   "Potentiation and arming of lymphocyte mediated immunity by sera from
RT   melanoma patients.";
RL   Eur. J. Cancer 11:267-276(1975).
//
RX   PubMed=1101782; DOI=10.1111/j.1749-6632.1975.tb29200.x;
RA   The T.H., Huiges H.A., Schraffordt Koops H., Lamberts H.B.,
RA   Nieweg H.O.;
RT   "Surface antigens on cultured malignant melanoma cells as detected by
RT   a membrane immunofluorescence method with human sera. Lack of
RT   tumor-specific reactions on melanoma lines.";
RL   Ann. N. Y. Acad. Sci. 254:528-540(1975).
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RX   PubMed=1104492; DOI=10.1002/ijc.2910160612;
RA   Cornain S., de Vries J.E., Collard J., Vennegoor C., van Wingerden I.,
RA   Rumke P.;
RT   "Antibodies and antigen expression in human melanoma detected by the
RT   immune adherence test.";
RL   Int. J. Cancer 16:981-997(1975).
//
RX   PubMed=1697409;
RA   Chenevix-Trench G., Martin N.G., Ellem K.A.O.;
RT   "Gene expression in melanoma cell lines and cultured melanocytes:
RT   correlation between levels of c-src-1, c-myc and p53.";
RL   Oncogene 5:1187-1193(1990).
//
RX   PubMed=4549213; DOI=10.1002/ijc.2910140402;
RA   de Vries J.E., Cornain S., Rumke P.;
RT   "Cytotoxity of non-T versus T-lymphocytes from melanoma patients and
RT   healthy donors on short- and long-term cultured melanoma cells.";
RL   Int. J. Cancer 14:427-434(1974).
//
RX   PubMed=6090953; DOI=10.1038/311671a0;
RA   Padua R.A., Barrass N.C., Currie G.A.;
RT   "A novel transforming gene in a human malignant melanoma cell line.";
RL   Nature 311:671-673(1984).
//
RX   PubMed=9354451;
RA   Castellano M., Pollock P.M., Walters M.K., Sparrow L.E., Down L.M.,
RA   Gabrielli B.G., Parsons P.G., Hayward N.K.;
RT   "CDKN2A/p16 is inactivated in most melanoma cell lines.";
RL   Cancer Res. 57:4868-4875(1997).
//
RX   PubMed=23039341; DOI=10.1186/1476-4598-11-75;
RA   Byron S.A., Loch D.C., Wellens C.L., Wortmann A., Wu J.-Y., Wang J.,
RA   Nomoto K., Pollock P.M.;
RT   "Sensitivity to the MEK inhibitor E6201 in melanoma cells is
RT   associated with mutant BRAF and wildtype PTEN status.";
RL   Mol. Cancer 11:75.1-75.15(2012).
//