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Cellosaurus imWilms10 (CVCL_DF34)

[Text version]
Cell line name imWilms10
Synonyms ImWilms10 T; ImWilms10T; IM-WT-10
Accession CVCL_DF34
Resource Identification Initiative To cite this cell line use: imWilms10 (RRID:CVCL_DF34)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Gene deletion; HGNC; HGNC:12796; WT1; Zygosity=Homozygous; Note=Nested within a heterozygous 11p13 deletion (PubMed=27213811).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Homozygous (PubMed=27213811).
Disease Kidney Wilms tumor (NCIt: C40407)
Nephroblastoma (ORDO: Orphanet_654)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A5SL (Wilms10T)
Sex of cell Female
Age at sampling 2Y
Category Conditionally immortalized cell line
STR profile Source(s): CLS=300419; PubMed=33379206

Markers:
AmelogeninX
CSF1PO11,12
D3S135817
D5S81810,12
D7S82011,12
D8S117910,15
D13S31712
D16S5399,10
D18S5114,16
D21S1129,30
FGA22,24
Penta D10,13
Penta E7,10
TH018
TPOX8,11
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=27213811; DOI=10.1371/journal.pone.0155561; PMCID=PMC4876997
Brandt A., Lohers K., Beier M., Leube B., de Torres C., Mora J., Arora P., Jat P.S., Royer-Pokora B.
Establishment of a conditionally immortalized Wilms tumor cell line with a homozygous WT1 deletion within a heterozygous 11p13 deletion and UPD limited to 11p15.
PLoS ONE 11:e0155561.1-e0155561.22(2016)

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Royer-Pokora B., Busch M.A., Tenbusch S., Schmidt M., Beier M., Woods A.D., Thiele H., Mora J.
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references
Cell line collections (Providers) CLS; 300419
Encyclopedic resources Wikidata; Q54897686
Gene expression databases GEO; GSM1831637
GEO; GSM1831638
Polymorphism and mutation databases Cosmic; 2569182
Entry history
Entry creation13-Jul-2016
Last entry update10-Apr-2025
Version number17