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Cellosaurus imWilms10 (CVCL_DF34)

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Cell line name imWilms10
Synonyms ImWilms10 T; ImWilms10T; IM-WT-10
Accession CVCL_DF34
Resource Identification Initiative To cite this cell line use: imWilms10 (RRID:CVCL_DF34)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Gene deletion; HGNC; HGNC:12796; WT1; Zygosity=Homozygous; Note=Nested within a heterozygous 11p13 deletion (PubMed=27213811).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Homozygous (PubMed=27213811).
Disease Kidney Wilms tumor (NCIt: C40407)
Nephroblastoma (ORDO: Orphanet_654)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A5SL (Wilms10T)
Sex of cell Female
Age at sampling 2Y
Category Conditionally immortalized cell line
STR profile Source(s): CLS=300419; PubMed=33379206

Markers:
AmelogeninX
CSF1PO11,12
D3S135817
D5S81810,12
D7S82011,12
D8S117910,15
D13S31712
D16S5399,10
D18S5114,16
D21S1129,30
FGA22,24
Penta D10,13
Penta E7,10
TH018
TPOX8,11
vWA15,18

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Publications

PubMed=27213811; DOI=10.1371/journal.pone.0155561; PMCID=PMC4876997
Artur Brandt, Katharina Lohers, Manfred Beier, Barbara Leube, Carmen de Torres, Jaume Mora, Parineeta Arora, Parmjit S. Jat, Brigitte Royer-Pokora;
Establishment of a conditionally immortalized Wilms tumor cell line with a homozygous WT1 deletion within a heterozygous 11p13 deletion and UPD limited to 11p15.
PLoS ONE 11:e0155561.1-e0155561.22(2016)

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Brigitte Royer-Pokora, Maike Anna Busch, Sarah Tenbusch, Mathias Schmidt, Manfred Beier, Andrew D. Woods, Holger Thiele, Jaume Mora;
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references
Cell line collections (Providers) CLS; 300419
Encyclopedic resources Wikidata; Q54897686
Gene expression databases GEO; GSM1831637
GEO; GSM1831638
Polymorphism and mutation databases Cosmic; 2569182
Entry history
Entry creation13-Jul-2016
Last entry update14-Aug-2025
Version number18