Cellosaurus cell line Wilms10T (CVCL

Cellosaurus Wilms10T (CVCL_A5SL)

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Cell line name

Wilms10T

Synonyms

Wilms10

Accession

CVCL_A5SL

Resource Identification Initiative

To cite this cell line use: Wilms10T (RRID:CVCL_A5SL)

Comments

Population: Caucasian.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.

Sequence variations

Gene deletion; HGNC; HGNC:12796; WT1; Zygosity=Homozygous; Note=Nested within a heterozygous 11p13 deletion (PubMed=27213811; PubMed=33379206).
Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Homozygous (PubMed=27213811; PubMed=33379206).

Disease

Kidney Wilms tumor (NCIt: C40407)
Nephroblastoma (ORDO: Orphanet_654)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_DF34 (imWilms10)

Originate from same individual

CVCL_A5SK ! Wilms10M

Sex of cell

Female

Age at sampling

Category

Finite cell line

STR profile

Source(s): CLS=300417; PubMed=33379206

Markers:

Amelogenin	X
CSF1PO	11,12
D3S1358	17
D5S818	10,12
D7S820	11,12
D8S1179	10,15
D13S317	12 (CLS=300417) 12,13 (PubMed=33379206)
D16S539	9,10
D18S51	14,16
D21S11	29,30
FGA	22,24
Penta D	10,13
Penta E	7,10
TH01	8
TPOX	8,11
vWA	15,18

Publications

PubMed=27213811; DOI=10.1371/journal.pone.0155561; PMCID=PMC4876997
Artur Brandt, Katharina Lohers, Manfred Beier, Barbara Leube, Carmen de Torres, Jaume Mora, Parineeta Arora, Parmjit S. Jat, Brigitte Royer-Pokora;
Establishment of a conditionally immortalized Wilms tumor cell line with a homozygous WT1 deletion within a heterozygous 11p13 deletion and UPD limited to 11p15.
PLoS ONE 11:e0155561.1-e0155561.22(2016)

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Brigitte Royer-Pokora, Maike Anna Busch, Sarah Tenbusch, Mathias Schmidt, Manfred Beier, Andrew D. Woods, Holger Thiele, Jaume Mora;
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references

Cell line collections (Providers)

CLS; 300417

Encyclopedic resources

Wikidata; Q107117465

Gene expression databases

GEO; GSM1831635
GEO; GSM1831636

Entry history

Entry creation

20-May-2021

Last entry update

10-Apr-2025

Version number