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Cellosaurus HG2L6.1c3 (CVCL_DC31)

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Cell line name HG2L6.1c3
Accession CVCL_DC31
Resource Identification Initiative To cite this cell line use: HG2L6.1c3 (RRID:CVCL_DC31)
Comments Population: Caucasian.
Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=21394221; DOI=10.1007/s11426-010-0142-8; PMCID=PMC3049243
Bin Zhao, David S. Baston, Elaine Khan, Claudio Sorrentino, Michael S. Denison;
Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds.
Sci. China Chem. 53:1010-1016(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DC31
Encyclopedic resources Wikidata; Q54885926
Entry history
Entry creation13-Jul-2016
Last entry update27-Nov-2025
Version number20