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Cellosaurus HG2L6.1c1 (CVCL_DC30)

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Cell line name HG2L6.1c1
Accession CVCL_DC30
Resource Identification Initiative To cite this cell line use: HG2L6.1c1 (RRID:CVCL_DC30)
Comments Population: Caucasian.
Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Web pages Provider; XDSI; -; http://www.dioxins.com/products/
Publications

PubMed=26366531; DOI=10.1021/acs.est.5b02906; PMCID=PMC4772899
Jennifer C. Brennan, Guo-Chun He, Tomoaki Tsutsumi, Jing Zhao, Edward Wirth, Michael H. Fulton, Michael S. Denison;
Development of species-specific Ah receptor-responsive third generation CALUX cell lines with enhanced responsiveness and improved detection limits.
Environ. Sci. Technol. 49:11903-11912(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DC30
Encyclopedic resources Wikidata; Q54885925
Entry history
Entry creation13-Jul-2016
Last entry update27-Nov-2025
Version number21