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Cellosaurus SRD-9 (CVCL_DA10)

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Cell line name SRD-9
Synonyms Sterol Regulatory Defective-9
Accession CVCL_DA10
Resource Identification Initiative To cite this cell line use: SRD-9 (RRID:CVCL_DA10)
Comments Selected for resistance to: ChEBI; CHEBI_42977; 25-hydroxycholesterol.
Transformant: ChEBI; CHEBI_23995; N-ethyl-N-nitrosourea (ENU).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Mutation; UniProtKB; P97260; Scap; Simple; p.Tyr298Cys (c.893A>G); Zygosity=Heterozygous (PubMed=9789003).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_D893 (CHO-7)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=9789003; DOI=10.1073/pnas.95.22.12848; PMCID=PMC23627
Axel Nohturfft, Michael Stuart Brown, Joseph Leonard Goldstein;
Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.
Proc. Natl. Acad. Sci. U.S.A. 95:12848-12853(1998)

PubMed=12482938; DOI=10.1073/pnas.262669399; PMCID=PMC139202
Daisuke Yabe, Zong-Ping Xia, Christopher M. Adams, Robert B. Rawson;
Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.
Proc. Natl. Acad. Sci. U.S.A. 99:16672-16677(2002)

Cross-references
Encyclopedic resources Wikidata; Q54955674
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number11