ID   SRD-9
AC   CVCL_DA10
SY   Sterol Regulatory Defective-9
DR   Wikidata; Q54955674
RX   PubMed=9789003;
RX   PubMed=12482938;
CC   Selected for resistance to: ChEBI; CHEBI:42977; 25-hydroxycholesterol.
CC   Sequence variation: Mutation; UniProtKB; P97260; Scap; Simple; p.Tyr298Cys (c.893A>G); Zygosity=Heterozygous (PubMed=9789003).
CC   Transformant: ChEBI; CHEBI:23995; N-ethyl-N-nitrosourea (ENU).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_D893 ! CHO-7
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 13-07-16; Last updated: 30-01-24; Version: 10
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RX   PubMed=9789003; DOI=10.1073/pnas.95.22.12848;
RA   Nohturfft A., Brown M.S., Goldstein J.L.;
RT   "Sterols regulate processing of carbohydrate chains of wild-type SREBP
RT   cleavage-activating protein (SCAP), but not sterol-resistant mutants
RT   Y298C or D443N.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:12848-12853(1998).
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RX   PubMed=12482938; DOI=10.1073/pnas.262669399;
RA   Yabe D., Xia Z.-P., Adams C.M., Rawson R.B.;
RT   "Three mutations in sterol-sensing domain of SCAP block interaction
RT   with insig and render SREBP cleavage insensitive to sterols.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16672-16677(2002).
//