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Cellosaurus BT142 (CVCL_D718)

[Text version]
Cell line name BT142
Accession CVCL_D718
Resource Identification Initiative To cite this cell line use: BT142 (RRID:CVCL_D718)
Comments Group: Cancer stem cell line.
Population: Caucasian.
Derived from site: In situ; Brain, left frontal lobe; UBERON=UBERON_0002811.
Sequence variations
  • Mutation; HGNC; 5382; IDH1; Simple; p.Arg132His (c.395G>A); ClinVar=VCV000156444; Zygosity=Heterozygous (PubMed=22166263).
Disease Oligoastrocytoma (NCIt: C4050)
Oligoastrocytoma (ORDO: Orphanet_251656)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_X501 (BT142 mut/-)
Sex of cell Male
Age at sampling 38Y
Category Cancer cell line

PubMed=22166263; DOI=10.1093/neuonc/nor207
Luchman H.A., Stechishin O.D.M., Dang N.H., Blough M.D., Chesnelong C., Kelly J.J.P., Nguyen S.A., Chan J.A.W., Weljie A.M., Cairncross J.G., Weiss S.
An in vivo patient-derived model of endogenous IDH1-mutant glioma.
Neuro-oncol. 14:184-191(2012)

PubMed=33504762; DOI=10.1038/s41467-020-20752-6
Lita A., Pliss A., Kuzmin A., Yamasaki T., Zhang L.-M., Dowdy T., Burks C., de Val N., Celiku O., Ruiz-Rodado V., Nicoli E.-R., Kruhlak M., Andresson T., Das S., Yang C.-Z., Schmitt R., Herold-Mende C., Gilbert M.R., Prasad P.N., Larion M.
IDH1 mutations induce organelle defects via dysregulated phospholipids.
Nat. Commun. 12:614.1-614.16(2021)

Cell line databases/resources cancercelllines; CVCL_D718
Encyclopedic resources Wikidata; Q54798487
Polymorphism and mutation databases Cosmic; 1629581
Cosmic; 2012330
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number17