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Cellosaurus OV-1847 (CVCL_D703)

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Cell line name OV-1847
Synonyms Ovary 1847; Ovary1847; OVARY1847
Accession CVCL_D703
Resource Identification Initiative To cite this cell line use: OV-1847 (RRID:CVCL_D703)
Comments Problematic cell line: Contaminated. Shown to be a OVCAR-8 derivative (PubMed=22710073).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00467.
Population: Caucasian.
Omics: Transcriptomics; Microarray.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gln26Arg (c.77A>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Gly776Val (c.2327G>T); ClinVar=VCV000163410; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Pro121His (c.362C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1629 (OVCAR-8)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=22328975; DOI=10.1158/2159-8290.CD-11-0170; PMCID=PMC3274821
Aphrothiti J. Hanrahan, Nikolaus Schultz, Maggie L. Westfal, Rita A. Sakr, Dilip D. Giri, Stefano Scarperi, Manickam Janakiraman, Narciso Olvera, Ellen V. Stevens, Qing-Bai She, Carol Aghajanian ...Show all 20 authors... , Tari A. King, Elisa de Stanchina, David R. Spriggs, Adriana Heguy, Barry Stephen Taylor, Chris Sander, Neal Rosen, Douglas A. Levine, David B. Solit; Show fewer authors
Genomic complexity and AKT dependence in serous ovarian cancer.
Cancer Discov. 2:56-67(2012)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D703
Biological sample resources BioSample; SAMN03151864
Encyclopedic resources Wikidata; Q54936822
Gene expression databases GEO; GSM851927
Polymorphism and mutation databases Cosmic; 1709260
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number26