ID   OV-1847
AC   CVCL_D703
SY   Ovary 1847; Ovary1847; OVARY1847
DR   BioSample; SAMN03151864
DR   cancercelllines; CVCL_D703
DR   Cosmic; 1709260
DR   GEO; GSM851927
DR   Wikidata; Q54936822
RX   PubMed=22328975;
RX   PubMed=22710073;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a OVCAR-8 derivative (PubMed=22710073).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00467.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gln26Arg (c.77A>G); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Gly776Val (c.2327G>T); ClinVar=VCV000163410; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Pro121His (c.362C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
DI   NCIt; C105555; High grade ovarian serous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1629 ! OVCAR-8
SX   Female
AG   64Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 26
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677;
RA   Korch, Christopher T.
RA   Spillman, Monique Ann
RA   Jackson, Twila A.
RA   Jacobsen, Britta M.
RA   Murphy, Susan K.
RA   Lessey, Bruce Arthur
RA   Jordan, Virgil Craig
RA   Bradford, Andrew Peter
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=22328975; DOI=10.1158/2159-8290.CD-11-0170; PMCID=PMC3274821;
RA   Hanrahan, Aphrothiti J.
RA   Schultz, Nikolaus
RA   Westfal, Maggie L.
RA   Sakr, Rita A.
RA   Giri, Dilip D.
RA   Scarperi, Stefano
RA   Janakiraman, Manickam
RA   Olvera, Narciso
RA   Stevens, Ellen V.
RA   She, Qing-Bai
RA   Aghajanian, Carol
RA   King, Tari Ann
RA   de Stanchina, Elisa
RA   Spriggs, David R.
RA   Heguy, Adriana
RA   Taylor, Barry Stephen
RA   Sander, Chris
RA   Rosen, Neal
RA   Levine, Douglas A.
RA   Solit, David B.
RT   "Genomic complexity and AKT dependence in serous ovarian cancer.";
RL   Cancer Discov. 2:56-67(2012).
//