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Cellosaurus DMS 53 HTT KO (CVCL_D6U0)

[Text version]
Cell line name DMS 53 HTT KO
Accession CVCL_D6U0
Resource Identification Initiative To cite this cell line use: DMS 53 HTT KO (RRID:CVCL_D6U0)
Comments From: Fanti, Rebeka; Structural Genomics Consortium, University of Toronto; Toronto; Canada.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4851; HTT.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu56Ter (c.166G>T); ClinVar=VCV001329425; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Heterozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1177 (DMS 53)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=39257448; DOI=10.12688/f1000research.153670.1; PMCID=PMC11384196
Rebeka Fanti, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Sara Gonzalez Bolivar, Renu Chandrasekaran, Kathleen Southern, Aled Morgan Edwards, Rachel Jane Harding, Carl Laflamme;
ABIF Consortium
NeuroSGC/YCharOS/EDDU Collaborative Group
A guide to selecting high-performing antibodies for huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescence.
F1000Research 13:922.1-922.12(2024)

Entry history
Entry creation10-Sep-2024
Last entry update10-Apr-2025
Version number3