ID   DMS 53 HTT KO
AC   CVCL_D6U0
RX   PubMed=39257448;
CC   From: Fanti, Rebeka; Structural Genomics Consortium, University of Toronto; Toronto; Canada.
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4851; HTT.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu56Ter (c.166G>T); ClinVar=VCV001329425; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1177 ! DMS 53
SX   Male
AG   54Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 10-04-25; Version: 3
//
RX   PubMed=39257448; DOI=10.12688/f1000research.153670.1; PMCID=PMC11384196;
RA   Fanti R., Ayoubi R., Alende C., Fotouhi M., Gonzalez Bolivar S.,
RA   Chandrasekaran R., Southern K., Edwards A.M., Harding R.J., Laflamme C.;
RG   ABIF Consortium;
RG   NeuroSGC/YCharOS/EDDU Collaborative Group;
RT   "A guide to selecting high-performing antibodies for huntingtin
RT   (UniProt ID: P42858) for use in western blot, immunoprecipitation,
RT   and immunofluorescence.";
RL   F1000Research 13:922.1-922.12(2024).
//