Cellosaurus cell line HyCyte 22Rv1 KO-hPTEN (CVCL

Cross-references
Cell line name	HyCyte 22Rv1 KO-hPTEN
Synonyms	hPTEN knockout 22RV1
Accession	CVCL_D6A2
Resource Identification Initiative	To cite this cell line use: HyCyte 22Rv1 KO-hPTEN (RRID:CVCL_D6A2)
Comments	Population: Caucasian. Doubling time: 24-48 hours (Hysigen=CGKO-M2454). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:9588; PTEN. Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Leu597Arg (c.1790T>G); ClinVar=VCV000013968; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Arg1252Ter (c.3754C>T); ClinVar=VCV000167228; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Gln3158Ter (c.9472C>T); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gln546Arg (c.1637A>G); ClinVar=VCV000045466; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Heterozygous (from parent cell line).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1045 (22Rv1)
Sex of cell	Male
Age at sampling	Adult
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGKO-M2454
Encyclopedic resources	Wikidata; Q127381966
Entry history
Entry creation	02-May-2024
Last entry update	19-Dec-2024
Version number	3