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Cellosaurus HepG2 82FR-31NR (CVCL_D5JJ)

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Cell line name HepG2 82FR-31NR
Synonyms 82FR-31NR; 82 days Fractionated Radiation-31 days Non-Radiation
Accession CVCL_D5JJ
Resource Identification Initiative To cite this cell line use: HepG2 82FR-31NR (RRID:CVCL_D5JJ)
Comments Population: Caucasian.
Characteristics: Radioresistant. Exposed to X-ray (0.5 Gy) fractionated radiation (FR) for 82 days and cessation of FR for 31 days (PubMed=23552696).
Selected for resistance to: NCIt; C17262; X-Ray.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): TKG=TKG 0803

Markers:
AmelogeninX
CSF1PO10,11
D5S81811,12
D7S82010
D13S31713
D16S53912,13
TH019
TPOX9
vWA17

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Publications

PubMed=23552696; DOI=10.1038/oncsis.2012.12; PMCID=PMC3412645
Tsutomu Shimura, Naoto Noma, Toshiyuki Oikawa, Yasushi Ochiai, Satoshi Kakuda, Yoshikazu Kuwahara, Yoshihiro Takai, Akihisa Takahashi, Manabu Fukumoto;
Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells.
Oncogenesis 1:e12.1-e12.9(2012)

Cross-references
Cell line collections (Providers) TKG; TKG 0803
Encyclopedic resources Wikidata; Q127381750
Entry history
Entry creation02-May-2024
Last entry update19-Dec-2024
Version number3