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Cellosaurus MDA-MB-231-luc2 (CVCL_D582)

[Text version]
Cell line name MDA-MB-231-luc2
Synonyms MDA-MB-231-Luc2
Accession CVCL_D582
Resource Identification Initiative To cite this cell line use: MDA-MB-231-luc2 (RRID:CVCL_D582)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Transfected with: UniProtKB; P08659; Firefly luciferase (with optimized codon usage for mammalian expression).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
CVCL_1D89 (MDA-MB-231-luc2-GFP)CVCL_1D92 (MDA-MB-231-luc2-LN)CVCL_1D90 (MDA-MB-231-luc2-tdTomato)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

Kim J.B., Wong K., Urban K.
Generation of invasive breast cancer cell lines for in vivo imaging.
Cancer Res. 73 Suppl. 8:3908-3908(2013)

Cell line collections (Providers) PerkinElmer; 124319 - Discontinued
Cell line databases/resources cancercelllines; CVCL_D582
Anatomy/cell type resources BTO; BTO:0005172
Encyclopedic resources Wikidata; Q54904600
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number24