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Cellosaurus K562/R7 (CVCL_D573)

[Text version]
Cell line name K562/R7
Synonyms K-562/R7; RK562
Accession CVCL_D573
Resource Identification Initiative To cite this cell line use: K562/R7 (RRID:CVCL_D573)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

CLPUB00273
Laura Ginot, Pierre Jeannesson, Jean-Francois Angiboust, Jean-Claude Jardillier, Michel Manfait;
Interactions of adriamycin in sensitive and resistant leukemic cells: a comparative study by microspectrofluorometry.
Studia Biophys. 104:145-153(1984)

Cross-references
Anatomy/cell type resources BTO; BTO_0005195
Chemistry resources ChEMBL-Cells; CHEMBL3833705
PubChem_Cell_line; CVCL_D573
Encyclopedic resources Wikidata; Q54899417
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number23