Cellosaurus cell line LS180-SPNS2-KO-c15 (CVCL

Cellosaurus LS180-SPNS2-KO-c15 (CVCL_D4WL)

Cross-references
Cell line name	LS180-SPNS2-KO-c15
Synonyms	CE0794-A
Accession	CVCL_D4WL
Resource Identification Initiative	To cite this cell line use: LS180-SPNS2-KO-c15 (RRID:CVCL_D4WL)
Comments	Part of: Research Empowerment on Solute Carriers (RESOLUTE) KO cell line panel. Population: Caucasian. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:26992; SPNS2. Derived from site: In situ; Colon; UBERON=UBERON_0001155. Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations	Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line). Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (from parent cell line).
Disease	Colon adenocarcinoma (NCIt: C4349)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0397 (LS180)
Sex of cell	Female
Age at sampling	58Y
Category	Cancer cell line
Web pages	Info; RESOLUTE; CE0794-A; https://re-solute.eu/resources/reagents
Encyclopedic resources	Wikidata; Q127382700
Entry history
Entry creation	30-Jan-2024
Last entry update	10-Apr-2025
Version number	4