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Cellosaurus HuH7-SLCO2A1-KO-c2 (CVCL_D4UQ)

[Text version]
Cell line name HuH7-SLCO2A1-KO-c2
Synonyms CE05B8-N
Accession CVCL_D4UQ
Resource Identification Initiative To cite this cell line use: HuH7-SLCO2A1-KO-c2 (RRID:CVCL_D4UQ)
Comments Part of: Research Empowerment on Solute Carriers (RESOLUTE) KO cell line panel.
Population: Japanese.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:10955; SLCO2A1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
Web pages Info; RESOLUTE; CE05B8-N; https://re-solute.eu/resources/reagents
Cross-references
Encyclopedic resources Wikidata; Q127381947
Entry history
Entry creation30-Jan-2024
Last entry update14-Aug-2025
Version number5