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Cellosaurus HEK293 FRT FURIN KO (CVCL_D4C5)

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Cell line name HEK293 FRT FURIN KO
Synonyms DeltaFur293; HEK293 DeltaFUR
Accession CVCL_D4C5
Resource Identification Initiative To cite this cell line use: HEK293 FRT FURIN KO (RRID:CVCL_D4C5)
Comments Characteristics: Contain a single stably integrated Flp recombinase recognition target (FRT) site at a transcriptionally active genomic locus (from parent cell line).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:8568; FURIN (Note=Exon 2 105 bp deletion).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D4C4 (HEK293 FRT)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
STR profile Source(s): PubMed=40485510

Markers:
AmelogeninX
CSF1PO12
D1S165615,17.3
D2S44111,15
D2S133819
D3S135815,17
D5S8188
D7S82011,12
D8S117912
D10S124814
D12S39119,21
D13S31712,14
D16S5399,13
D18S5117,18
D19S43318
D21S1128,30.2
D22S104516
FGA23
SE3317
TH017,9.3
TPOX11
vWA16,19

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Publications

PubMed=40485510; DOI=10.1242/bio.061792; PMCID=PMC12208400
Brian D. Grossman, Jack D. Sanford, Yu-Yi Zhu, Cynthia B. Zeller, John Edward Weldon;
Intracellular trafficking of furin enhances cellular intoxication by recombinant immunotoxins based on Pseudomonas exotoxin A.
Biol. Open 14:bio061792.1-bio061792.37(2025)

Cross-references
Encyclopedic resources Wikidata; Q127381644
Entry history
Entry creation30-Jan-2024
Last entry update27-Nov-2025
Version number7