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Cellosaurus Neuro2a-RXR (CVCL_D3XR)

[Text version]
Cell line name Neuro2a-RXR
Synonyms N2a-pVgRXR
Accession CVCL_D3XR
Resource Identification Initiative To cite this cell line use: Neuro2a-RXR (RRID:CVCL_D3XR)
Comments Characteristics: Transfected with the pVgRXR vector that contains the VgEcR fusion protein under the control of a CMV promoter and RXRA under the control of a RSV promoter as well as BleoR (PubMed=10574348).
Genetic integration: Method=Transfection/transduction; Gene=FlyBase_Gene; FBgn0000546; EcR (Note=With p.Met1_Val221del, as 2nd part of VgECR).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:10477; RXRA.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 (HHV-1) VP16 (UL28) (Note=With p.Met1_Thr412del, as 1st part of VgECR).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Derived from site: In situ; Peripheral nervous system; UBERON=UBERON_0000010.
Cell type: Neural crest derived neuroblast; CL=CL_0002676.
Disease Mouse neuroblastoma (NCIt: C21993)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: A/J.
Hierarchy Parent: CVCL_0470 (Neuro-2a)
Children:
CVCL_D3YR (Neuro2a-tNhtt-EGFP-16Q)CVCL_D3YT (Neuro2a-tNhtt-EGFP-150Q)CVCL_D3YS (Neuro2a-tNhtt-EGFP-60Q)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=10574348; DOI=10.1097/00001756-199908200-00001
Guang-Hui Wang, Kenichi Mitsui, Svetlana Kotliarova, Akira Yamashita, Yoshiro Nagao, Shinya Tokuhiro, Takeshi Iwatsubo, Ichiro Kanazawa, Nobuyuki Nukina;
Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells.
NeuroReport 10:2435-2438(1999)

Cross-references
Cell line collections (Providers) RCB; RCB5511
Encyclopedic resources Wikidata; Q127382946
Entry history
Entry creation30-Jan-2024
Last entry update14-Aug-2025
Version number5