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Cellosaurus ST IRF3/7 KO (CVCL_D3XI)

[Text version]
Cell line name ST IRF3/7 KO
Accession CVCL_D3XI
Resource Identification Initiative To cite this cell line use: ST IRF3/7 KO (RRID:CVCL_D3XI)
Comments Virology: Compared to the parent ST cell line supports a higher level of replication for several types of viruses, such as coronavirus (PEDV), picornavirus (SVA), paramyxovirus (PIV5), and alphavirus (GETV). This is due to the reduced production of interferon alphas and betas and related antiviral factors (PubMed=38047496).
Knockout cell: Method=CRISPR/Cas9; VGNC; 89206; IRF3.
Knockout cell: Method=CRISPR/Cas9; VGNC; 89210; IRF7.
Derived from site: In situ; Fetal testis; UBERON=UBERON_0000473.
Cell type: Sertoli cell; CL=CL_0000216.
Species of origin Sus scrofa (Pig) (NCBI Taxonomy: 9823)
Hierarchy Parent: CVCL_D3XG (ST IRF3 KO)
Sex of cell Male
Age at sampling 80-90FD
Category Spontaneously immortalized cell line

PubMed=38047496; DOI=10.1002/biot.202300389
Sun X.-M., Wang J., Mou C.-X., Shi K.-C., Bao W.-B., Chen Z.-H.
Knockout of IRF3 and IRF7 genes by CRISPR/Cas9 technology enhances porcine virus replication in the swine testicular (ST) cell line.
Biotechnol. J. 19:e2300389.1-e2300389.11(2024)

Entry history
Entry creation30-Jan-2024
Last entry update30-Jan-2024
Version number1