Cellosaurus ST IRF3/7 KO (CVCL_D3XI)
| Cell line name | ST IRF3/7 KO |
|---|---|
| Accession | CVCL_D3XI |
| Resource Identification Initiative | To cite this cell line use: ST IRF3/7 KO (RRID:CVCL_D3XI) |
| Comments | Virology: Compared to the parent ST cell line supports a higher level of replication for several types of viruses, such as coronavirus (PEDV), picornavirus (SVA), paramyxovirus (PIV5), and alphavirus (GETV). This is due to the reduced production of interferon alphas and betas and related antiviral factors (PubMed=38047496). Knockout cell: Method=CRISPR/Cas9; VGNC; 89206; IRF3. Knockout cell: Method=CRISPR/Cas9; VGNC; 89210; IRF7. Derived from site: In situ; Fetal testis; UBERON=UBERON_0000473. Cell type: Sertoli cell; CL=CL_0000216. |
| Species of origin | Sus scrofa (Pig) (NCBI Taxonomy: 9823) |
| Hierarchy | Parent: CVCL_D3XG (ST IRF3 KO) |
| Sex of cell | Male |
| Age at sampling | 80-90FD |
| Category | Spontaneously immortalized cell line |
| Publications | PubMed=38047496; DOI=10.1002/biot.202300389 |
| Entry history | |
| Entry creation | 30-Jan-2024 |
| Last entry update | 30-Jan-2024 |
| Version number | 1 |