ID   ST IRF3/7 KO
AC   CVCL_D3XI
RX   PubMed=38047496;
CC   Virology: Compared to the parent ST cell line supports a higher level of replication for several types of viruses, such as coronavirus (PEDV), picornavirus (SVA), paramyxovirus (PIV5), and alphavirus (GETV). This is due to the reduced production of interferon alphas and betas and related antiviral factors (PubMed=38047496).
CC   Knockout cell: Method=CRISPR/Cas9; VGNC; 89206; IRF3.
CC   Knockout cell: Method=CRISPR/Cas9; VGNC; 89210; IRF7.
CC   Derived from site: In situ; Fetal testis; UBERON=UBERON_0000473.
CC   Cell type: Sertoli cell; CL=CL_0000216.
OX   NCBI_TaxID=9823; ! Sus scrofa (Pig)
HI   CVCL_D3XG ! ST IRF3 KO
SX   Male
AG   80-90FD
CA   Spontaneously immortalized cell line
DT   Created: 30-01-24; Last updated: 30-01-24; Version: 1
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RX   PubMed=38047496; DOI=10.1002/biot.202300389;
RA   Sun X.-M., Wang J., Mou C.-X., Shi K.-C., Bao W.-B., Chen Z.-H.;
RT   "Knockout of IRF3 and IRF7 genes by CRISPR/Cas9 technology enhances
RT   porcine virus replication in the swine testicular (ST) cell line.";
RL   Biotechnol. J. 19:e2300389.1-e2300389.11(2024).
//