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Cellosaurus CHO/CLDN6 (CVCL_D3PQ)

[Text version]
Cell line name CHO/CLDN6
Synonyms CLDN6/CHO
Accession CVCL_D3PQ
Resource Identification Initiative To cite this cell line use: CHO/CLDN6 (RRID:CVCL_D3PQ)
Comments Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:2048; CLDN6 (Note=With a C-terminal mycHis6 tag).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCIt; C129640; Cobalt-60 gamma radiation.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Gene deletion; UniProtKB; Q2MH30; Dhfr; Zygosity=Homozygous (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_7180 (CHO-DG44)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=19555390; DOI=10.1111/j.1349-7006.2009.01239.x; PMCID=PMC11159503
Masayo Suzuki, Mariko Kato-Nakano, Shinobu Kawamoto, Akiko Furuya, Yuzuru Abe, Hirofumi Misaka, Naoya Kimoto, Kazuyasu Nakamura, So Ohta, Hiroshi Ando;
Therapeutic antitumor efficacy of monoclonal antibody against claudin-4 for pancreatic and ovarian cancers.
Cancer Sci. 100:1623-1630(2009)

Patent=US8076458
So Ohta, Hiroshi Ando, Masayo Suzuki, Shinobu Kawamoto, Mariko Kato-Nakano, Kazuyasu Nakamura;
Anti-claudin-4 antibody.
Patent number US8076458, 13-Dec-2011

PubMed=25744656; DOI=10.1080/09168451.2015.1018124
Hiroshi Ando, Masayo Suzuki, Mariko Kato-Nakano, Shinobu Kawamoto, Hirofumi Misaka, Naoya Kimoto, Akiko Furuya, Kazuyasu Nakamura;
Generation of specific monoclonal antibodies against the extracellular loops of human claudin-3 by immunizing mice with target-expressing cells.
Biosci. Biotechnol. Biochem. 79:1272-1279(2015)

Cross-references
Encyclopedic resources Wikidata; Q127380496
Entry history
Entry creation30-Jan-2024
Last entry update14-Aug-2025
Version number4