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Cellosaurus iBMK W2.Bcl2-3 (CVCL_D3H1)

[Text version]
Cell line name iBMK W2.Bcl2-3
Synonyms W2.Bcl2-3
Accession CVCL_D3H1
Resource Identification Initiative To cite this cell line use: iBMK W2.Bcl2-3 (RRID:CVCL_D3H1)
Comments Knockout cell: Method=KO mouse; MGI; MGI:99702; Bax (Note=1 of 2 alleles).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:990; BCL2.
Genetic integration: Method=Transfection; Gene=MGI; MGI:98834; Trp53 (Note=With p.Leu14_Lys302del = p53DD).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03255; Human adenovirus C serotype 5 E1A protein.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5 (Note=E1A).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Parent: CVCL_D3G2 (iBMK W2)
Children:
CVCL_D3JG (iBMK W2.Bcl2-3RED)
Sex of cell Sex unspecified
Age at sampling 5D
Category Transformed cell line
Publications

PubMed=15314031; DOI=10.1101/gad.1204904; PMCID=PMC515288
Deirdre A. Nelson, Ting-Ting Tan, Arnold B. Rabson, Diana Anderson, Kurt Degenhardt, Eileen White;
Hypoxia and defective apoptosis drive genomic instability and tumorigenesis.
Genes Dev. 18:2095-2107(2004)

PubMed=15766661; DOI=10.1016/j.ccr.2005.02.008
Ting-Ting Tan, Kurt Degenhardt, Deirdre A. Nelson, Brian Beaudoin, Wilberto Nieves-Neira, Philippe Bouillet, Andreas Villunger, Jerry McKee Adams, Eileen White;
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.
Cancer Cell 7:227-238(2005)

PubMed=16843265; DOI=10.1016/j.ccr.2006.06.001; PMCID=PMC2857533
Kurt Degenhardt, Robin Mathew, Brian Beaudoin, Kevin Bray, Diana Anderson, Guang-Hua Chen, Chandreyee Mukherjee, Yu-Fang Shi, Celine Gelinas, Yong-Jun Fan, Deirdre A. Nelson ...Show all 13 authors... , Sheng-Kan Jin, Eileen White; Show fewer authors
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis.
Cancer Cell 10:51-64(2006)

PubMed=18603117; DOI=10.1016/S0076-6879(08)01605-4
Robin Mathew, Kurt Degenhardt, Liti Haramaty, Cristina M. Karp, Eileen White;
Immortalized mouse epithelial cell models to study the role of apoptosis in cancer.
Methods Enzymol. 446:77-106(2008)

Cross-references
Encyclopedic resources Wikidata; Q127382258
Entry history
Entry creation30-Jan-2024
Last entry update14-Aug-2025
Version number5