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Cellosaurus PyMT-1099 (CVCL_D3FN)

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Cell line name PyMT-1099
Accession CVCL_D3FN
Resource Identification Initiative To cite this cell line use: PyMT-1099 (RRID:CVCL_D3FN)
Comments Characteristics: Undergoes epithelial-mesenchymal transition (EMT) in response to TGF-beta addition in vitro and undergoes a complete mesenchymal to epithelial transition (MET) upon TGF-beta withdrawal (PubMed=30108334).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03077; Murine polyomavirus (strain A2) (MPyV) middle T antigen (PyMT).
Transformant: NCBI_TaxID; 10636; Murine polyomavirus (strain A2) (MPyV).
Miscellaneous: Age at sampling from personal communication of Christofori, Gerhard M.
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: FVB/N MMTV-PyMT transgenic.
Sex of cell Female
Age at sampling 12-13W
Category Cancer cell line
STR profile Source(s): Millipore=SCC422

Markers:
Mouse STR 1-115,16
Mouse STR 1-216,17
Mouse STR 2-115,16
Mouse STR 3-214
Mouse STR 4-220.3
Mouse STR 5-515,16
Mouse STR 6-417,18
Mouse STR 6-715
Mouse STR 7-125.2
Mouse STR 8-116
Mouse STR 11-214,15
Mouse STR 12-116
Mouse STR 13-116.2,17
Mouse STR 15-321.3,22.3
Mouse STR 17-216,17
Mouse STR 18-318
Mouse STR 19-212
Mouse STR X-127,28

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Publications

PubMed=30108334; DOI=10.1038/s41598-018-30640-1; PMCID=PMC6092323
Meera Saxena, Ravi Kiran Reddy Kalathur, Melanie Neutzner, Gerhard M. Christofori;
PyMT-1099, a versatile murine cell model for EMT in breast cancer.
Sci. Rep. 8:12123.1-12123.12(2018)

Cross-references
Cell line collections (Providers) Millipore; SCC422
Encyclopedic resources Wikidata; Q127383992
Entry history
Entry creation30-Jan-2024
Last entry update10-Apr-2025
Version number5