ID   PyMT-1099
AC   CVCL_D3FN
DR   Millipore; SCC422
DR   Wikidata; Q127383992
RX   PubMed=30108334;
CC   Characteristics: Undergoes epithelial-mesenchymal transition (EMT) in response to TGF-beta addition in vitro and undergoes a complete mesenchymal to epithelial transition (MET) upon TGF-beta withdrawal (PubMed=30108334).
CC   Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03077; Murine polyomavirus (strain A2) (MPyV) middle T antigen (PyMT).
CC   Transformant: NCBI_TaxID; 10636; Murine polyomavirus (strain A2) (MPyV).
CC   Miscellaneous: Age at sampling from personal communication of Christofori, Gerhard M.
CC   Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
CC   Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
CC   Breed/subspecies: FVB/N MMTV-PyMT transgenic.
ST   Source(s): Millipore=SCC422
ST   Mouse STR 1-1: 15,16
ST   Mouse STR 1-2: 16,17
ST   Mouse STR 2-1: 15,16
ST   Mouse STR 3-2: 14
ST   Mouse STR 4-2: 20.3
ST   Mouse STR 5-5: 15,16
ST   Mouse STR 6-4: 17,18
ST   Mouse STR 6-7: 15
ST   Mouse STR 7-1: 25.2
ST   Mouse STR 8-1: 16
ST   Mouse STR 11-2: 14,15
ST   Mouse STR 12-1: 16
ST   Mouse STR 13-1: 16.2,17
ST   Mouse STR 15-3: 21.3,22.3
ST   Mouse STR 17-2: 16,17
ST   Mouse STR 18-3: 18
ST   Mouse STR 19-2: 12
ST   Mouse STR X-1: 27,28
DI   NCIt; C21678; Malignant neoplasms of the mouse mammary gland
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Female
AG   12-13W
CA   Cancer cell line
DT   Created: 30-01-24; Last updated: 10-04-25; Version: 5
//
RX   PubMed=30108334; DOI=10.1038/s41598-018-30640-1; PMCID=PMC6092323;
RA   Saxena, Meera
RA   Kalathur, Ravi Kiran Reddy
RA   Neutzner, Melanie
RA   Christofori, Gerhard M.
RT   "PyMT-1099, a versatile murine cell model for EMT in breast cancer.";
RL   Sci. Rep. 8:12123.1-12123.12(2018).
//