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Cellosaurus (CVCL_D2RG)

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Synonyms C32COLON
Accession CVCL_5246
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Microsatellite instability: Stable (MSS) (PubMed=24755471; PubMed=25926053).
Omics: Proteomics.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Asp777Leufs*2 (c.2329_2332delGACA); Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Ser42Ile (c.125G>T); Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=16418264).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): ECACC=12022908; PubMed=25926053

Markers:

Run an STR similarity search on this cell line
Publications






Specific modulation of dopamine expression in neuronal hybrid cells by primary cells from different brain regions.
Proc. Natl. Acad. Sci. U.S.A. 89:8943-8947(1992)


Daniel Michael Davis, Chang H. Jo, Jonathan E. Boyson, Jack Leonard Strominger;
Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity.
Proc. Natl. Acad. Sci. U.S.A. 96:5640-5644(1999)




Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645(2004)


Luis Alberto Diaz Jr., Tobias Sjoblom, Omer Barad, Zvi Bentwich, Anna E. Szafranska, Emmanuel Labourier, Christopher K. Raymond, Brian S. Roberts, Hartmut Juhl, Kenneth Wayne Kinzler, Bert Vogelstein, Victor E. Velculescu;
The colorectal microRNAome.
Proc. Natl. Acad. Sci. U.S.A. 103:3687-3692(2006)


Godefridus Johannes Peters;
Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.
Br. J. Cancer 96:769-775(2007)



stem cells by intracytoplasmic sperm injection.
Mol. Reprod. Dev. 74:1081-1088(2007)


William George Kaelin Jr., Sabina Signoretti;
Patterns of gene expression and copy-number alterations in von-Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney.
Cancer Res. 69:4674-4681(2009)




Cancer Res. 72:3424-3436(2012)




Nat. Commun. 5:3195.1-3195.13(2014)



antiviral response to VHSV in resistant and susceptible rainbow trout.
BMC Genomics 19:482.1-482.15(2018)

Cross-references
Cell line collections (Providers) CancerTools; 151756
ECACC; 12022908 - Discontinued
Ximbio; 151756
Cell line databases/resources cancercelllines; CVCL_5246
ColonAtlas; C32
Encyclopedic resources Wikidata; Q27902825
Gene expression databases GEO; GSM274682
GEO; GSM1346829
GEO; GSM1374421
GEO; GSM1448199
GEO; GSM3145606
GEO; GSM3145693
Polymorphism and mutation databases Cosmic; 948845
Cosmic; 986005
Cosmic; 995374
Cosmic; 1043555
Cosmic; 1223131
Cosmic; 1312291
Cosmic; 1479621
Cosmic; 2301959
Cosmic; 2760093
Cosmic; 2800567
IARC_TP53; 21764
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number31