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Cellosaurus RN46A (CVCL_D261)

[Text version]
Cell line name RN46A
Synonyms RN-46A
Accession CVCL_D261
Resource Identification Initiative To cite this cell line use: RN46A (RRID:CVCL_D261)
Comments Characteristics: At the restrictive temperature (39 Celsius) the cells are capable of differentiating.
Doubling time: 19 hours (ECACC=12061302).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Embryonic brain, medullary raphe nucleus; UBERON=UBERON_0002692.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Sprague Dawley; RS=RS_0000681.
Hierarchy Children:
CVCL_U016 (RN46A-B14)
Sex of cell Sex unspecified
Age at sampling 13FD
Category Transformed cell line
Publications

PubMed=7965075; DOI=10.1523/JNEUROSCI.14-11-06744.1994; PMCID=PMC6577239
White L.A., Eaton M.J., Castro M.C., Klose K.J., Globus M.Y.-T., Shaw G., Whittemore S.R.
Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons.
J. Neurosci. 14:6744-6753(1994)

PubMed=7601307; DOI=10.1006/dbio.1995.1205
Eaton M.J., Staley J.K., Globus M.Y.-T., Whittemore S.R.
Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization.
Dev. Biol. 170:169-182(1995)

PubMed=8690054; DOI=10.1006/exnr.1996.0121
Eaton M.J., Whittemore S.R.
Autocrine BDNF secretion enhances the survival and serotonergic differentiation of raphe neuronal precursor cells grafted into the adult rat CNS.
Exp. Neurol. 140:105-114(1996)

Cross-references
Cell line collections (Providers) ECACC; 12061302
Anatomy/cell type resources BTO; BTO_0003779
Encyclopedic resources Wikidata; Q54950749
Experimental variables resources EFO; EFO_0022804
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number16