ID   RN46A
AC   CVCL_D261
SY   RN-46A
DR   BTO; BTO_0003779
DR   EFO; EFO_0022804
DR   ECACC; 12061302
DR   Wikidata; Q54950749
RX   PubMed=7601307;
RX   PubMed=7965075;
RX   PubMed=8690054;
CC   Characteristics: At the restrictive temperature (39 Celsius) the cells are capable of differentiating.
CC   Doubling time: 19 hours (ECACC=12061302).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
CC   Derived from site: In situ; Embryonic brain, medullary raphe nucleus; UBERON=UBERON_0002692.
CC   Breed/subspecies: Sprague Dawley; RS=RS_0000681.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Sex unspecified
AG   13FD
CA   Transformed cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 16
//
RX   PubMed=7601307; DOI=10.1006/dbio.1995.1205;
RA   Eaton M.J., Staley J.K., Globus M.Y.-T., Whittemore S.R.;
RT   "Developmental regulation of early serotonergic neuronal
RT   differentiation: the role of brain-derived neurotrophic factor and
RT   membrane depolarization.";
RL   Dev. Biol. 170:169-182(1995).
//
RX   PubMed=7965075; DOI=10.1523/JNEUROSCI.14-11-06744.1994; PMCID=PMC6577239;
RA   White L.A., Eaton M.J., Castro M.C., Klose K.J., Globus M.Y.-T.,
RA   Shaw G., Whittemore S.R.;
RT   "Distinct regulatory pathways control neurofilament expression and
RT   neurotransmitter synthesis in immortalized serotonergic neurons.";
RL   J. Neurosci. 14:6744-6753(1994).
//
RX   PubMed=8690054; DOI=10.1006/exnr.1996.0121;
RA   Eaton M.J., Whittemore S.R.;
RT   "Autocrine BDNF secretion enhances the survival and serotonergic
RT   differentiation of raphe neuronal precursor cells grafted into the
RT   adult rat CNS.";
RL   Exp. Neurol. 140:105-114(1996).
//