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Cellosaurus Co-115 (CVCL_D102)

[Text version]
Cell line name Co-115
Synonyms CO-115; Co 115; CO115; Co115
Accession CVCL_D102
Resource Identification Initiative To cite this cell line use: Co-115 (RRID:CVCL_D102)
Comments Population: Caucasian.
Characteristics: Established from a tumor implanted into a nude mice.
Doubling time: ~36 hours (Note=At 26th passage) (PubMed=975046); 27.66 hours (PubMed=25944804).
Microsatellite instability: Instable (MSI) (PubMed=9000147; PubMed=24042735; PubMed=25926053; PubMed=28683746).
Omics: Glycomics; N-glycan profiling.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Miscellaneous: STR profile mentioned but not shown in PubMed=24042735; obtained from personal communication of Lind, Guro Elisabeth.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
Sequence variations
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 77Y
Category Cancer cell line
STR profile Source(s): PubMed=24042735; PubMed=25926053

Markers:
AmelogeninX
CSF1PO11,12,13,14 (PubMed=25926053)
11,13 (PubMed=24042735)
D2S133822,25
D3S135813,15,16
D5S81810,11 (PubMed=24042735)
10,12 (PubMed=25926053)
D7S8207 (PubMed=24042735)
7,10.3 (PubMed=25926053)
D8S117911,12
D13S31712,16 (PubMed=25926053)
13,16 (PubMed=24042735)
D16S53910,11
D18S5114,15
D19S43310,14,15
D21S1134.2,35 (PubMed=25926053)
35,35.2 (PubMed=24042735)
FGA19,21
TH019,9.3
TPOX8,9 (PubMed=24042735)
8,10 (PubMed=25926053)
vWA15,20

Run an STR similarity search on this cell line
Publications

PubMed=975046
Stefan Carrel, Bernard Sordat, Claude Merenda;
Establishment of a cell line (Co-115) from a human colon carcinoma transplanted into nude mice.
Cancer Res. 36:3978-3984(1976)

PubMed=3349466
Isabelle Chantret, Alain Barbat, Elisabeth Dussaulx, Michael G. Brattain, Alain Zweibaum;
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Cancer Res. 48:1936-1942(1988)

PubMed=1389533; DOI=10.1016/0959-8049(92)90031-V
Harald Lahm, Danuta Petral-Malec, Aysim Yilmaz-Ceyhan, Jurgen R. Fischer, Murielle Lorenzoni, Jean-Claude Givel, Nikolas Odartchenko;
Growth stimulation of a human colorectal carcinoma cell line by interleukin-1 and -6 and antagonistic effects of transforming growth factor beta 1.
Eur. J. Cancer 28A:1894-1899(1992)

PubMed=9000147
Paul-Henri Cottu, Francoise Muzeau, Anne Estreicher, Jean-Francois Flejou, Richard D. Iggo, Gilles Thomas, Richard Hamelin;
Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines.
Oncogene 13:2727-2730(1996)

PubMed=9000572
Jean-Marc Hoang, Paul-Henri Cottu, Benedicte Thuille, Remi J. Salmon, Gilles Thomas, Richard Hamelin;
BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.
Cancer Res. 57:300-303(1997)

PubMed=11414198; DOI=10.1007/s004320000207
Harald Lahm, Sabine Andre, Andreas Hoeflich, Jurgen R. Fischer, Bernard Sordat, Herbert Kaltner, Eckhard Wolf, Hans-Joachim Gabius;
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11526487; DOI=10.1038/sj.onc.1204611
Jacqueline Gayet, Xiao-Ping Zhou, Alex Duval, Sandra Rolland, Jean-Marc Hoang, Paul-Henri Cottu, Richard Hamelin;
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.
Oncogene 20:5025-5032(2001)

PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514
Manickam Janakiraman, Efsevia Vakiani, Zhao-Shi Zeng, Christine A. Pratilas, Barry Stephen Taylor, Dhananjay Chitale, Ensar Halilovic, Manda Wilson, Kety Huberman, Julio Cezar Marques Ricarte Filho, Yogindra Persaud ...Show all 21 authors... , Douglas A. Levine, James Alexander Fagin, Suresh C. Jhanwar, John M. Mariadason, Alex Lash, Marc Ladanyi, Leonard B. Saltz, Adriana Heguy, Philip B. Paty, David B. Solit; Show fewer authors
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Cancer Res. 70:5901-5911(2010)

PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225
Deeqa Ahmed, Peter W. Eide, Ina A. Eilertsen, Stine A. Danielsen, Mette Eknaes, Merete Hektoen, Guro Elisabeth Lind, Ragnhild Adelheid Lothe;
Epigenetic and genetic features of 24 colon cancer cell lines.
Oncogenesis 2:e71.1-e71.8(2013)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457
Sarah Bazzocco, Higinio Dopeso, Fernando Carton-Garcia, Irati Macaya, Elena Andretta, Fiona Chionh, Paulo Rodrigues, Miriam Garrido, Hafid Alazzouzi, Rocio Nieto, Alex Sanchez ...Show all 15 authors... , Simo Schwartz Jr., Josipa Bilic, John M. Mariadason, Diego Arango; Show fewer authors
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Clin. Cancer Res. 21:3695-3704(2015)

PubMed=26537799; DOI=10.1074/mcp.M115.051235; PMCID=PMC4762531
Stephanie Holst, Anna J.M. Deuss, Gabi W. van Pelt, Sandra Johanna van Vliet, Juan J. Garcia-Vallejo, Carolien A.M. Koeleman, Andre M. Deelder, Wilma E. Mesker, Rob A.E.M. Tollenaar, Yoann Rombouts, Manfred Wuhrer;
N-glycosylation profiling of colorectal cancer cell lines reveals association of fucosylation with differentiation and caudal type homebox 1 (CDX1)/villin mRNA expression.
Mol. Cell. Proteomics 15:124-140(2016)

PubMed=28683746; DOI=10.1186/s12943-017-0691-y; PMCID=PMC5498998
Kaja Christine Graue Berg, Peter W. Eide, Ina A. Eilertsen, Bjarne Johannessen, Jarle Bruun, Stine A. Danielsen, Merete Bjornslett, Leonardo Andres Meza-Zepeda, Mette Eknaes, Guro Elisabeth Lind, Ola Myklebost ...Show all 14 authors... , Rolf Inge Skotheim, Anita Sveen, Ragnhild Adelheid Lothe; Show fewer authors
Multi-omics of 34 colorectal cancer cell lines -- a resource for biomedical studies.
Mol. Cancer 16:116.1-116.16(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D102
ColonAtlas; CO115
TOKU-E; 4097
Encyclopedic resources Wikidata; Q54813921
Gene expression databases GEO; GSM1448067
GEO; GSM2549993
Metabolomic databases MetaboLights; MTBLS227
Polymorphism and mutation databases Cosmic; 711254
Cosmic; 887213
Cosmic; 1057757
Cosmic; 1132574
Cosmic; 1303885
Cosmic; 1479610
Cosmic; 2036658
Entry history
Entry creation22-Oct-2012
Last entry update14-Aug-2025
Version number32