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Cellosaurus Co-115 (CVCL_D102)

[Text version]

Cell line name Co-115
Synonyms CO-115; Co 115; CO115; Co115
Accession CVCL_D102
Resource Identification Initiative To cite this cell line use: Co-115 (RRID:CVCL_D102)
Comments Population: Caucasian.
Characteristics: Established from a tumor implanted into a nude mice.
Doubling time: ~36 hours, at 26th passage (PubMed=975046).
Microsatellite instability: Instable (MSI) (PubMed=9000147; PubMed=24042735; PubMed=25926053; PubMed=28683746).
Omics: N-glycan profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Miscellaneous: STR profile mentioned but not shown in PubMed=24042735; obtained by personal communication of Lind G.E.
Derived from sampling site: Colon; ascending.
Sequence variations
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 77Y
Category Cancer cell line
STR profile Source(s): PubMed=24042735; PubMed=25926053

Markers:
AmelogeninX
CSF1PO11,12,13,14 (PubMed=25926053)
11,13 (PubMed=24042735)
D2S133822,25
D3S135813,15,16
D5S81810,11 (PubMed=24042735)
10,12 (PubMed=25926053)
D7S8207 (PubMed=24042735)
7,10.3 (PubMed=25926053)
D8S117911,12
D13S31712,16 (PubMed=25926053)
13,16 (PubMed=24042735)
D16S53910,11
D18S5114,15
D19S43310,14,15
D21S1134.2,35 (PubMed=25926053)
35,35.2 (PubMed=24042735)
FGA19,21
TH019,9.3
TPOX8,9 (PubMed=24042735)
8,10 (PubMed=25926053)
vWA15,20

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Publications

PubMed=975046
Carrel S., Sordat B., Merenda C.
Establishment of a cell line (Co-115) from a human colon carcinoma transplanted into nude mice.
Cancer Res. 36:3978-3984(1976)

PubMed=3349466
Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Cancer Res. 48:1936-1942(1988)

PubMed=1389533; DOI=10.1016/0959-8049(92)90031-V
Lahm H., Petral-Malec D., Yilmaz-Ceyhan A., Fischer J.R., Lorenzoni M., Givel J.-C., Odartchenko N.
Growth stimulation of a human colorectal carcinoma cell line by interleukin-1 and -6 and antagonistic effects of transforming growth factor beta 1.
Eur. J. Cancer 28:1894-1899(1992)

PubMed=9000147
Cottu P.H., Muzeau F., Estreicher A., Flejou J.-F., Iggo R.D., Thomas G., Hamelin R.
Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines.
Oncogene 13:2727-2730(1996)

PubMed=9000572
Hoang J.-M., Cottu P.H., Thuille B., Salmon R.J., Thomas G., Hamelin R.
BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.
Cancer Res. 57:300-303(1997)

PubMed=11414198; DOI=10.1007/s004320000207
Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.J.
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11526487; DOI=10.1038/sj.onc.1204611
Gayet J., Zhou X.-P., Duval A., Rolland S., Hoang J.-M., Cottu P.H., Hamelin R.
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.
Oncogene 20:5025-5032(2001)

PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192
Janakiraman M., Vakiani E., Zeng Z.-S., Pratilas C.A., Taylor B.S., Chitale D., Halilovic E., Wilson M., Huberman K., Ricarte Filho J.C., Persaud Y., Levine D.A., Fagin J.A., Jhanwar S.C., Mariadason J.M., Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Cancer Res. 70:5901-5911(2010)

PubMed=24042735; DOI=10.1038/oncsis.2013.35
Ahmed D., Eide P.W., Eilertsen I.A., Danielsen S.A., Eknaes M., Hektoen M., Lind G.E., Lothe R.A.
Epigenetic and genetic features of 24 colon cancer cell lines.
Oncogenesis 2:e71.1-e71.8(2013)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=26537799; DOI=10.1074/mcp.M115.051235
Holst S., Deuss A.J.M., van Pelt G.W., van Vliet S.J., Garcia-Vallejo J.J., Koeleman C.A.M., Deelder A.M., Mesker W.E., Tollenaar R.A., Rombouts Y., Wuhrer M.
N-glycosylation profiling of colorectal cancer cell lines reveals association of fucosylation with differentiation and caudal type homebox 1 (CDX1)/villin mRNA expression.
Mol. Cell. Proteomics 15:124-140(2016)

PubMed=28683746; DOI=10.1186/s12943-017-0691-y
Berg K.C.G., Eide P.W., Eilertsen I.A., Johannessen B., Bruun J., Danielsen S.A., Bjornslett M., Meza-Zepeda L.A., Eknaes M., Lind G.E., Myklebost O., Skotheim R.I., Sveen A., Lothe R.A.
Multi-omics of 34 colorectal cancer cell lines -- a resource for biomedical studies.
Mol. Cancer 16:116.1-116.16(2017)

Cross-references
Cell line databases/resources ColonAtlas; CO115
TOKU-E; 4097
Encyclopedic resources Wikidata; Q54813921
Gene expression databases GEO; GSM1448067
GEO; GSM2549993
Metabolomic databases MetaboLights; MTBLS227
Polymorphism and mutation databases Cosmic; 711254
Cosmic; 887213
Cosmic; 1057757
Cosmic; 1132574
Cosmic; 1303885
Cosmic; 1479610
Cosmic; 2036658
Entry history
Entry creation22-Oct-2012
Last entry update23-Sep-2021
Version number24