ID   Co-115
AC   CVCL_D102
SY   CO-115; Co 115; CO115; Co115
DR   cancercelllines; CVCL_D102
DR   ColonAtlas; CO115
DR   Cosmic; 711254
DR   Cosmic; 887213
DR   Cosmic; 1057757
DR   Cosmic; 1132574
DR   Cosmic; 1303885
DR   Cosmic; 1479610
DR   Cosmic; 2036658
DR   GEO; GSM1448067
DR   GEO; GSM2549993
DR   MetaboLights; MTBLS227
DR   TOKU-E; 4097
DR   Wikidata; Q54813921
RX   PubMed=975046;
RX   PubMed=1389533;
RX   PubMed=3349466;
RX   PubMed=9000147;
RX   PubMed=9000572;
RX   PubMed=11414198;
RX   PubMed=11526487;
RX   PubMed=20570890;
RX   PubMed=24042735;
RX   PubMed=25926053;
RX   PubMed=25944804;
RX   PubMed=26537799;
RX   PubMed=28683746;
CC   Population: Caucasian.
CC   Characteristics: Established from a tumor implanted into a nude mice.
CC   Doubling time: ~36 hours (Note=At 26th passage) (PubMed=975046); 27.66 hours (PubMed=25944804).
CC   Microsatellite instability: Instable (MSI) (PubMed=9000147; PubMed=24042735; PubMed=25926053; PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=20570890; PubMed=24042735; PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu157Glyfs*23 (c.469dupG) (c.469_470insG); ClinVar=VCV000655856; Zygosity=Unspecified (PubMed=24042735; PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Unspecified (PubMed=24042735; PubMed=28683746).
CC   Omics: Glycomics; N-glycan profiling.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Miscellaneous: STR profile mentioned but not shown in PubMed=24042735; obtained from personal communication of Lind, Guro Elisabeth.
CC   Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
ST   Source(s): PubMed=24042735; PubMed=25926053
ST   Amelogenin: X
ST   CSF1PO: 11,12,13,14 (PubMed=25926053)
ST   CSF1PO: 11,13 (PubMed=24042735)
ST   D13S317: 12,16 (PubMed=25926053)
ST   D13S317: 13,16 (PubMed=24042735)
ST   D16S539: 10,11
ST   D18S51: 14,15
ST   D19S433: 10,14,15
ST   D21S11: 34.2,35 (PubMed=25926053)
ST   D21S11: 35,35.2 (PubMed=24042735)
ST   D2S1338: 22,25
ST   D3S1358: 13,15,16
ST   D5S818: 10,11 (PubMed=24042735)
ST   D5S818: 10,12 (PubMed=25926053)
ST   D7S820: 7 (PubMed=24042735)
ST   D7S820: 7,10.3 (PubMed=25926053)
ST   D8S1179: 11,12
ST   FGA: 19,21
ST   TH01: 9,9.3
ST   TPOX: 8,9 (PubMed=24042735)
ST   TPOX: 8,10 (PubMed=25926053)
ST   vWA: 15,20
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   77Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 14-08-25; Version: 32
//
RX   PubMed=28683746; DOI=10.1186/s12943-017-0691-y; PMCID=PMC5498998;
RA   Berg, Kaja Christine Graue
RA   Eide, Peter W.
RA   Eilertsen, Ina A.
RA   Johannessen, Bjarne
RA   Bruun, Jarle
RA   Danielsen, Stine A.
RA   Bjornslett, Merete
RA   Meza-Zepeda, Leonardo Andres
RA   Eknaes, Mette
RA   Lind, Guro Elisabeth
RA   Myklebost, Ola
RA   Skotheim, Rolf Inge
RA   Sveen, Anita
RA   Lothe, Ragnhild Adelheid
RT   "Multi-omics of 34 colorectal cancer cell lines -- a resource for
RT   biomedical studies.";
RL   Mol. Cancer 16:116.1-116.16(2017).
//
RX   PubMed=11414198; DOI=10.1007/s004320000207;
RA   Lahm, Harald
RA   Andre, Sabine
RA   Hoeflich, Andreas
RA   Fischer, Jurgen R.
RA   Sordat, Bernard
RA   Kaltner, Herbert
RA   Wolf, Eckhard
RA   Gabius, Hans-Joachim
RT   "Comprehensive galectin fingerprinting in a panel of 61 human tumor
RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
RL   J. Cancer Res. Clin. Oncol. 127:375-386(2001).
//
RX   PubMed=9000147;
RA   Cottu, Paul-Henri
RA   Muzeau, Francoise
RA   Estreicher, Anne
RA   Flejou, Jean-Francois
RA   Iggo, Richard D.
RA   Thomas, Gilles
RA   Hamelin, Richard
RT   "Inverse correlation between RER+ status and p53 mutation in
RT   colorectal cancer cell lines.";
RL   Oncogene 13:2727-2730(1996).
//
RX   PubMed=26537799; DOI=10.1074/mcp.M115.051235; PMCID=PMC4762531;
RA   Holst, Stephanie
RA   Deuss, Anna J.M.
RA   van Pelt, Gabi W.
RA   van Vliet, Sandra Johanna
RA   Garcia-Vallejo, Juan J.
RA   Koeleman, Carolien A.M.
RA   Deelder, Andre M.
RA   Mesker, Wilma E.
RA   Tollenaar, Robertus Alexandre Eduard Mattheus
RA   Rombouts, Yoann
RA   Wuhrer, Manfred
RT   "N-glycosylation profiling of colorectal cancer cell lines reveals
RT   association of fucosylation with differentiation and caudal type
RT   homebox 1 (CDX1)/villin mRNA expression.";
RL   Mol. Cell. Proteomics 15:124-140(2016).
//
RX   PubMed=9000572;
RA   Hoang, Jean-Marc
RA   Cottu, Paul-Henri
RA   Thuille, Benedicte
RA   Salmon, Remi J.
RA   Thomas, Gilles
RA   Hamelin, Richard
RT   "BAT-26, an indicator of the replication error phenotype in colorectal
RT   cancers and cell lines.";
RL   Cancer Res. 57:300-303(1997).
//
RX   PubMed=975046;
RA   Carrel, Stefan
RA   Sordat, Bernard
RA   Merenda, Claude
RT   "Establishment of a cell line (Co-115) from a human colon carcinoma
RT   transplanted into nude mice.";
RL   Cancer Res. 36:3978-3984(1976).
//
RX   PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514;
RA   Janakiraman, Manickam
RA   Vakiani, Efsevia
RA   Zeng, Zhao-Shi
RA   Pratilas, Christine A.
RA   Taylor, Barry Stephen
RA   Chitale, Dhananjay
RA   Halilovic, Ensar
RA   Wilson, Manda
RA   Huberman, Kety
RA   Ricarte Filho, Julio Cezar Marques
RA   Persaud, Yogindra
RA   Levine, Douglas A.
RA   Fagin, James Alexander
RA   Jhanwar, Suresh C.
RA   Mariadason, John M.
RA   Lash, Alex
RA   Ladanyi, Marc
RA   Saltz, Leonard B.
RA   Heguy, Adriana
RA   Paty, Philip B.
RA   Solit, David B.
RT   "Genomic and biological characterization of exon 4 KRAS mutations in
RT   human cancer.";
RL   Cancer Res. 70:5901-5911(2010).
//
RX   PubMed=3349466;
RA   Chantret, Isabelle
RA   Barbat, Alain
RA   Dussaulx, Elisabeth
RA   Brattain, Michael G.
RA   Zweibaum, Alain
RT   "Epithelial polarity, villin expression, and enterocytic
RT   differentiation of cultured human colon carcinoma cells: a survey of
RT   twenty cell lines.";
RL   Cancer Res. 48:1936-1942(1988).
//
RX   PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225;
RA   Ahmed, Deeqa
RA   Eide, Peter W.
RA   Eilertsen, Ina A.
RA   Danielsen, Stine A.
RA   Eknaes, Mette
RA   Hektoen, Merete
RA   Lind, Guro Elisabeth
RA   Lothe, Ragnhild Adelheid
RT   "Epigenetic and genetic features of 24 colon cancer cell lines.";
RL   Oncogenesis 2:e71.1-e71.8(2013).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico, Enzo
RA   Russo, Mariangela
RA   Picco, Gabriele
RA   Cancelliere, Carlotta
RA   Valtorta, Emanuele
RA   Corti, Giorgio
RA   Buscarino, Michela
RA   Isella, Claudio
RA   Lamba, Simona
RA   Martinoglio, Barbara
RA   Veronese, Silvio
RA   Siena, Salvatore
RA   Sartore-Bianchi, Andrea
RA   Beccuti, Marco
RA   Mottolese, Marcella
RA   Linnebacher, Michael
RA   Cordero, Francesca
RA   Di Nicolantonio, Federica
RA   Bardelli, Alberto
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//
RX   PubMed=11526487; DOI=10.1038/sj.onc.1204611;
RA   Gayet, Jacqueline
RA   Zhou, Xiao-Ping
RA   Duval, Alex
RA   Rolland, Sandra
RA   Hoang, Jean-Marc
RA   Cottu, Paul-Henri
RA   Hamelin, Richard
RT   "Extensive characterization of genetic alterations in a series of
RT   human colorectal cancer cell lines.";
RL   Oncogene 20:5025-5032(2001).
//
RX   PubMed=1389533; DOI=10.1016/0959-8049(92)90031-V;
RA   Lahm, Harald
RA   Petral-Malec, Danuta
RA   Yilmaz-Ceyhan, Aysim
RA   Fischer, Jurgen R.
RA   Lorenzoni, Murielle
RA   Givel, Jean-Claude
RA   Odartchenko, Nikolas
RT   "Growth stimulation of a human colorectal carcinoma cell line by
RT   interleukin-1 and -6 and antagonistic effects of transforming growth
RT   factor beta 1.";
RL   Eur. J. Cancer 28A:1894-1899(1992).
//
RX   PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457;
RA   Bazzocco, Sarah
RA   Dopeso, Higinio
RA   Carton-Garcia, Fernando
RA   Macaya, Irati
RA   Andretta, Elena
RA   Chionh, Fiona
RA   Rodrigues, Paulo
RA   Garrido, Miriam
RA   Alazzouzi, Hafid
RA   Nieto, Rocio
RA   Sanchez, Alex
RA   Schwartz, Simo Jr.
RA   Bilic, Josipa
RA   Mariadason, John M.
RA   Arango, Diego
RT   "Highly expressed genes in rapidly proliferating tumor cells as new
RT   targets for colorectal cancer treatment.";
RL   Clin. Cancer Res. 21:3695-3704(2015).
//