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Cellosaurus UC 729-6 (CVCL_D039)

[Text version]
Cell line name UC 729-6
Synonyms UC729-6; UC729.6
Accession CVCL_D039
Resource Identification Initiative To cite this cell line use: UC 729-6 (RRID:CVCL_D039)
Comments Group: Hybridoma fusion partner cell line.
Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8061.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Sequence variations
  • Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6544 (WIL2)
CVCL_3664 (CLNH11.4)CVCL_3665 (CLNH5.5)CVCL_Z072 (VLN1F9)
CVCL_8009 (VLN3G2)CVCL_Z074 (VLN5C7)CVCL_8010 (VLN6H2)
CVCL_6741 (WI-L2-729HF2)CVCL_H618 (WLNA6)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/u/cell-lines-detail-447.html

PubMed=6350451; DOI=10.4049/jimmunol.131.3.1201
Abrams P.G., Knost J.A., Clarke G., Wilburn S., Oldham R.K., Foon K.A.
Determination of the optimal human cell lines for development of human hybridomas.
J. Immunol. 131:1201-1204(1983)

PubMed=6604917; DOI=10.1073/pnas.80.20.6327
Glassy M.C., Handley H.H., Hagiwara H., Royston I.
UC 729-6, a human lymphoblastoid B-cell line useful for generating antibody-secreting human-human hybridomas.
Proc. Natl. Acad. Sci. U.S.A. 80:6327-6331(1983)

Royston I., Handley H.H., Seegmiller J.E., Thompson L.F.
Immunoglobulin-secreting human hybridomas from a cultured human lymphoblastoid cell line.
Patent number US4451570, 29-May-1984

Glassy M.C.
Generation of UC 729-6 and SHEFP-1 derived human hybridomas and their growth in serum-free media.
J. Tissue Cult. Methods 12:85-89(1989)

Encyclopedic resources Wikidata; Q54973901
Entry history
Entry creation22-Oct-2012
Last entry update29-Jun-2023
Version number20