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Cellosaurus WI-L2-729HF2 (CVCL_6741)

[Text version]
Cell line name WI-L2-729HF2
Synonyms WI-L2-729-HF2; WI-L2-729 HF2; 729-HF2; UC729-HF2; UC729HF2; HF2
Accession CVCL_6741
Resource Identification Initiative To cite this cell line use: WI-L2-729HF2 (RRID:CVCL_6741)
Comments Group: Hybridoma fusion partner cell line.
Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8062.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Misspelling: W1-L2-729-HF2; PubMed=3101287.
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Sequence variations
  • Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D039 (UC 729-6)
Children:
CVCL_B6E2 (HD7/1A1.15.24)CVCL_2488 (HF2x653)CVCL_A6HX (HH09A2)
CVCL_A6HY (HH09A3)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
STR profile Source(s): ATCC=CRL-8062

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81812,13
D7S8209,11
D13S31711
D16S53911,12
TH018,9.3
TPOX8,11
vWA17,20

Run an STR similarity search on this cell line
Publications

PubMed=6350451; DOI=10.4049/jimmunol.131.3.1201
Abrams P.G., Knost J.A., Clarke G., Wilburn S., Oldham R.K., Foon K.A.
Determination of the optimal human cell lines for development of human hybridomas.
J. Immunol. 131:1201-1204(1983)

PubMed=6699402; DOI=10.4049/jimmunol.132.4.1798
Strike L.E., Devens B.H., Lundak R.L.
Production of human-human hybridomas secreting antibody to sheep erythrocytes after in vitro immunization.
J. Immunol. 132:1798-1803(1984)

Patent=US4594325
Lundak R.L.
High fusion frequency fusible lymphoblastoid cell line.
Patent number US4594325, 10-Jun-1986

PubMed=3101287; DOI=10.1111/j.1423-0410.1986.tb01955.x
Lowe A.D., Green S.M., Voak D., Gibson T., Lennox E.S.
A human-human monoclonal anti-D by direct fusion with a lymphoblastoid line.
Vox Sang. 51:212-216(1986)

PubMed=3365703
Kjeldsen T.B., Rasmussen B.B., Rose C., Zeuthen J.
Human-human hybridomas and human monoclonal antibodies obtained by fusion of lymph node lymphocytes from breast cancer patients.
Cancer Res. 48:3208-3214(1988)

Cross-references
Cell line collections (Providers) ATCC; CRL-8062 - Discontinued
Cell line databases/resources CLO; CLO_0009603
Encyclopedic resources Wikidata; Q54994037
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number18