Cellosaurus cell line M6/B7 (CVCL

Cellosaurus M6/B7 (CVCL_D034)

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Cell line name

M6/B7

Synonyms

EST45

Accession

CVCL_D034

Resource Identification Initiative

To cite this cell line use: M6/B7 (RRID:CVCL_D034)

Comments

Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1700; CD80.
Omics: Variations; Array-based CGH.
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=17260012).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=17260012; PubMed=23851445).

HLA typing

Source: PubMed=15592718

Class I
HLA-A	A*01:01,23:01
HLA-B	B*07:02,49:01
HLA-C	C*07:01:01,07:02
Class II
HLA-DP	DPB1*04:01,03:01
HLA-DQ	DQB1*06:02
HLA-DR	DRB1*01:01,15:01

Disease

Cutaneous melanoma (NCIt: C3510)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_T324 (CaCL 73-36)

Sex of cell

Female

Age at sampling

50Y

Category

Cancer cell line

STR profile

Source(s): ESTDAB=ESTDAB-045

Markers:

Amelogenin	X
CSF1PO	12
D3S1358	17,18
D5S818	11,13
D7S820	9,10
D13S317	11,12
FGA	23,23.2
TH01	6,9
TPOX	8
vWA	15,17

Publications

PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966
Teresa Rodriguez, Rosa Mendez, Chrissy H. Roberts, Francisco Ruiz-Cabello Osuna, I. Anthony Dodi, Miguel Angel Lopez-Nevot, Laura Paco, Isabel Maleno, Steven G.E. Marsh, Graham Pawelec, Federico Garrido;
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Goran Jonsson, Christina Dahl, Johan Staaf, Troy Sandberg, Par-Ola Bendahl, Markus Ringner, Per Guldberg, Ake Borg;
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Christina Dahl, Claus Christensen, Goran Jonsson, Anders Lorentzen, Mette Louise Skjodt, Ake Borg, Graham Pawelec, Per Guldberg;
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_D034
ESTDAB; ESTDAB-045

Encyclopedic resources

Wikidata; Q54903638

Gene expression databases

GEO; GSM156007

Polymorphism and mutation databases

Cosmic; 1047646
Cosmic; 2163790
IARC_TP53; 26073
Progenetix; CVCL_D034

Entry history

Entry creation

22-Oct-2012

Last entry update

10-Apr-2025

Version number