ID   M6/B7
AC   CVCL_D034
SY   EST45
DR   cancercelllines; CVCL_D034
DR   Cosmic; 1047646
DR   Cosmic; 2163790
DR   ESTDAB; ESTDAB-045
DR   GEO; GSM156007
DR   IARC_TP53; 26073
DR   Progenetix; CVCL_D034
DR   Wikidata; Q54903638
RX   PubMed=15592718;
RX   PubMed=17260012;
RX   PubMed=23851445;
CC   HLA typing: A*01:01,23:01; B*07:02,49:01; C*07:01:01,07:02; DPB1*04:01,03:01; DQB1*06:02; DRB1*01:01,15:01 (PubMed=15592718).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=17260012).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=17260012; PubMed=23851445).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1700; CD80.
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
ST   Source(s): ESTDAB=ESTDAB-045
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11,12
ST   D3S1358: 17,18
ST   D5S818: 11,13
ST   D7S820: 9,10
ST   FGA: 23,23.2
ST   TH01: 6,9
ST   TPOX: 8
ST   vWA: 15,17
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_T324 ! CaCL 73-36
SX   Female
AG   50Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 24
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RX   PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966;
RA   Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A.,
RA   Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G.,
RA   Garrido F.;
RT   "High frequency of homozygosity of the HLA region in melanoma cell
RT   lines reveals a pattern compatible with extensive loss of
RT   heterozygosity.";
RL   Cancer Immunol. Immunother. 54:141-148(2005).
//
RX   PubMed=17260012; DOI=10.1038/sj.onc.1210252;
RA   Jonsson G., Dahl C., Staaf J., Sandberg T., Bendahl P.-O., Ringner M.,
RA   Guldberg P., Borg A.;
RT   "Genomic profiling of malignant melanoma using tiling-resolution
RT   arrayCGH.";
RL   Oncogene 26:4738-4748(2007).
//
RX   PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006;
RA   Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L.,
RA   Borg A., Pawelec G., Guldberg P.;
RT   "Mutual exclusivity analysis of genetic and epigenetic drivers in
RT   melanoma identifies a link between p14 ARF and RARbeta signaling.";
RL   Mol. Cancer Res. 11:1166-1178(2013).
//