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Cellosaurus NCI-N87/Cas9-hyg (CVCL_C9DN)

[Text version]
Cell line name NCI-N87/Cas9-hyg
Accession CVCL_C9DN
Resource Identification Initiative To cite this cell line use: NCI-N87/Cas9-hyg (RRID:CVCL_C9DN)
Comments Characteristics: Stably expresses a EF1a-Cas9-HA-SV40-EGFP-IRES-HygR construct (GeneCopoeia=SL565).
Genetic integration: Method=Transfection; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
Genetic integration: Method=Transfection; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 3431; ERBB3; Simple; p.Thr757Lys (c.2270C>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Gastric tubular adenocarcinoma (NCIt: C5473)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1603 (NCI-N87)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Cross-references
Cell line collections (Providers) GeneCopoeia; SL565
Encyclopedic resources Wikidata; Q123033160
Entry history
Entry creation05-Oct-2023
Last entry update10-Sep-2024
Version number3