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Cellosaurus 14169 (CVCL_C9CL)

[Text version]
Cell line name 14169
Accession CVCL_C9CL
Resource Identification Initiative To cite this cell line use: 14169 (RRID:CVCL_C9CL)
Comments Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Sequence variations
  • Gene fusion; HGNC; HGNC:13575; BRD4 + HGNC; HGNC:29919; NUTM1; Name(s)=BRD4-NUTM1, BRD4-NUT; Note=BRD4 exon 15 fused to NUTM1 exon 2 (PubMed=24736545).
Disease NUT carcinoma (NCIt: C45716)
NUT midline carcinoma (ORDO: Orphanet_443167)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
Publications

PubMed=24736545; DOI=10.1158/0008-5472.CAN-13-2658; PMCID=PMC4097982
Ran-Ran Wang, Wei Liu, Christine M. Helfer, James E. Bradner, Jason L. Hornick, Susan M. Janicki, Christopher Alexander French, Jian-Xin You;
Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives neoplastic transformation in NUT midline carcinoma.
Cancer Res. 74:3332-3343(2014)

PubMed=29348827; DOI=10.18632/oncotarget.22862; PMCID=PMC5762512
Anja Stirnweiss, Joyce Oommen, Rishi S. Kotecha, Ursula R. Kees, Alex H. Beesley;
Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease.
Oncotarget 8:112313-112329(2017)

Cross-references
Encyclopedic resources Wikidata; Q123030221
Entry history
Entry creation05-Oct-2023
Last entry update10-Apr-2025
Version number4