ID   14169
AC   CVCL_C9CL
DR   Wikidata; Q123030221
RX   PubMed=24736545;
RX   PubMed=29348827;
CC   Sequence variation: Gene fusion; HGNC; HGNC:13575; BRD4 + HGNC; HGNC:29919; NUTM1; Name(s)=BRD4-NUTM1, BRD4-NUT; Note=BRD4 exon 15 fused to NUTM1 exon 2 (PubMed=24736545).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
DI   NCIt; C45716; NUT carcinoma
DI   ORDO; Orphanet_443167; NUT midline carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 10-04-25; Version: 4
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RX   PubMed=24736545; DOI=10.1158/0008-5472.CAN-13-2658; PMCID=PMC4097982;
RA   Wang R.-R., Liu W., Helfer C.M., Bradner J.E., Hornick J.L.,
RA   Janicki S.M., French C.A., You J.-X.;
RT   "Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives
RT   neoplastic transformation in NUT midline carcinoma.";
RL   Cancer Res. 74:3332-3343(2014).
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RX   PubMed=29348827; DOI=10.18632/oncotarget.22862; PMCID=PMC5762512;
RA   Stirnweiss A., Oommen J., Kotecha R.S., Kees U.R., Beesley A.H.;
RT   "Molecular-genetic profiling and high-throughput in vitro drug
RT   screening in NUT midline carcinoma-an aggressive and fatal disease.";
RL   Oncotarget 8:112313-112329(2017).
//