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Cellosaurus HEK293T/ACE2 (CVCL_C9BE)

[Text version]
Cell line name HEK293T/ACE2
Synonyms HEK293T-hACE2
Accession CVCL_C9BE
Resource Identification Initiative To cite this cell line use: HEK293T/ACE2 (RRID:CVCL_C9BE)
Comments Group: SARS-CoV-2 research cell line.
Characteristics: Expresses ACE2 under the control of the CMV promoter (GeneCopoeia=SL221).
Transfected with: HGNC; 13557; ACE2.
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=tsA].
Omics: CRISPR phenotypic screen.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0063 (HEK293T)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=35086559; DOI=10.1186/s13073-022-01013-1
Grodzki M., Bluhm A.P., Schaefer M., Tagmount A., Russo M., Sobh A., Rafiee R., Vulpe C.D., Karst S.M., Norris M.H.
Genome-scale CRISPR screens identify host factors that promote human coronavirus infection.
Genome Med. 14:10.1-10.18(2022)

Cross-references
Cell line collections (Providers) GeneCopoeia; SL221
CRISP screens repositories BioGRID_ORCS_Cell_line; 1668
Encyclopedic resources Wikidata; Q123031593
Entry history
Entry creation05-Oct-2023
Last entry update30-Jan-2024
Version number2