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Cellosaurus KP-Cas9-Clone 7 (CVCL_C9B0)

[Text version]
Cell line name KP-Cas9-Clone 7
Accession CVCL_C9B0
Resource Identification Initiative To cite this cell line use: KP-Cas9-Clone 7 (RRID:CVCL_C9B0)
Comments Knockout cell: Method=KO mouse; MGI; MGI:98834; Trp53.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
Genetic integration: Method=Transgenic mouse; Gene=MGI; MGI:96680; Kras (Note=With p.Gly12Asp).
Omics: Phenotyping; CRISPR screening.
Disease Adenocarcinoma of the mouse pulmonary system (NCIt: C21771)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6 KrasLSL-G12D/+, Trp53flox/flox (KP).
Hierarchy Parent: CVCL_C9AY (KP-Clone 7)
Category Cancer cell line
Publications

PubMed=31744829; DOI=10.1158/2159-8290.CD-19-0780; PMCID=PMC7007372
Fei Li, Qing-Yuan Huang, Troy A. Luster, Hai Hu, Hua Zhang, Wai-Lung Ng, Alireza Khodadadi-Jamayran, Wei Wang, Ting Chen, Jie-Hui Deng, Michela Ranieri ...Show all 28 authors... , Zhao-Yuan Fang, Val Pyon, Catriona M. Dowling, Ece Bagdatlioglu, Christina Almonte, Kristen Labbe, Heather Silver, Alexandra R. Rabin, Kandarp Jani, Aristotelis Tsirigos, Thales Y. Papagiannakopoulos, Peter S. Hammerman, Vamsidhar Velcheti, Gordon James Freeman, Jun Qi, George Miller, Kwok-Kin Wong; Show fewer authors
In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma.
Cancer Discov. 10:270-287(2020)

Cross-references
CRISP screens repositories BioGRID_ORCS_Cell_line; 1122
Encyclopedic resources Wikidata; Q123032845
Entry history
Entry creation05-Oct-2023
Last entry update14-Aug-2025
Version number6