ID   KP-Cas9-Clone 7
AC   CVCL_C9B0
DR   BioGRID_ORCS_Cell_line; 1122
DR   Wikidata; Q123032845
RX   PubMed=31744829;
CC   Knockout cell: Method=KO mouse; MGI; MGI:98834; Trp53.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
CC   Genetic integration: Method=Transgenic mouse; Gene=MGI; MGI:96680; Kras (Note=With p.Gly12Asp).
CC   Omics: Phenotyping; CRISPR screening.
CC   Breed/subspecies: C57BL/6 KrasLSL-G12D/+, Trp53flox/flox (KP).
DI   NCIt; C21771; Adenocarcinoma of the mouse pulmonary system
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_C9AY ! KP-Clone 7
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 10-04-25; Version: 5
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RX   PubMed=31744829; DOI=10.1158/2159-8290.CD-19-0780; PMCID=PMC7007372;
RA   Li F., Huang Q.-Y., Luster T.A., Hu H., Zhang H., Ng W.-L.,
RA   Khodadadi-Jamayran A., Wang W., Chen T., Deng J.-H., Ranieri M.,
RA   Fang Z.-Y., Pyon V., Dowling C.M., Bagdatlioglu E., Almonte C., Labbe K.,
RA   Silver H., Rabin A.R., Jani K., Tsirigos A., Papagiannakopoulos T.Y.,
RA   Hammerman P.S., Velcheti V., Freeman G.J., Qi J., Miller G.,
RA   Wong K.-K.;
RT   "In vivo epigenetic CRISPR screen identifies Asf1a as an
RT   immunotherapeutic target in Kras-mutant lung adenocarcinoma.";
RL   Cancer Discov. 10:270-287(2020).
//