| Cell line name |
A549-deltaSTAT1 |
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| Synonyms |
A549 STAT1-/- |
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| Accession |
CVCL_C9AT |
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| Resource Identification Initiative |
To cite this cell line use: A549-deltaSTAT1 (RRID:CVCL_C9AT) |
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| Comments |
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11362; STAT1.
Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
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| Sequence variations |
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Lung adenocarcinoma (NCIt: C3512) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0023 (A-549)
Children:
|
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| Sex of cell |
Male |
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| Age at sampling |
58Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=29321309; DOI=10.1128/JVI.02021-17; PMCID=PMC5972909
Teresa Allende Aydillo-Gomez, Juan Ayllon-Barasoain, Amzie Pavlisin, Carles Martinez-Romero, Shashank Tripathi, Ignacio Mena, Andres Moreira-Soto, Amanda Vicente-Santos, Eugenia Corrales-Aguilar, Martin Schwemmle, Adolfo Garcia-Sastre;
Specific mutations in the PB2 protein of influenza A virus compensate for the lack of efficient interferon antagonism of the NS1 protein of bat influenza A-like viruses.
J. Virol. 92:e02021.17.1-e02021.17.18(2018) PubMed=35421191; DOI=10.1371/journal.ppat.1010464; PMCID=PMC9041830
Oded Danziger, Roosheel Sandeep Patel, Emma J. DeGrace, Mikaela R. Rosen, Brad R. Rosenberg;
Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor.
PLoS Pathog. 18:e1010464.1-e1010464.31(2022) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q123030360
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| Entry history |
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| Entry creation | 05-Oct-2023 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 3 |
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