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Cellosaurus A549-deltaSTAT1 (CVCL_C9AT)

[Text version]
Cell line name A549-deltaSTAT1
Synonyms A549 STAT1-/-
Accession CVCL_C9AT
Resource Identification Initiative To cite this cell line use: A549-deltaSTAT1 (RRID:CVCL_C9AT)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 11362; STAT1.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Children:
CVCL_C9AU (A549-deltaSTAT1-SunTag)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=29321309; DOI=10.1128/JVI.02021-17
Aydillo-Gomez T.A., Ayllon-Barasoain J., Pavlisin A., Martinez-Romero C., Tripathi S., Mena I., Moreira-Soto A., Vicente-Santos A., Corrales-Aguilar E., Schwemmle M., Garcia-Sastre A.
Specific mutations in the PB2 protein of influenza A virus compensate for the lack of efficient interferon antagonism of the NS1 protein of bat influenza A-like viruses.
J. Virol. 92:e02021.17.1-e02021.17.18(2018)

PubMed=35421191; DOI=10.1371/journal.ppat.1010464
Danziger O., Patel R.S., DeGrace E.J., Rosen M.R., Rosenberg B.R.
Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor.
PLoS Pathog. 18:E1010464-E1010464(2022)

Cross-references
Encyclopedic resources Wikidata; Q123030360
Entry history
Entry creation05-Oct-2023
Last entry update30-Jan-2024
Version number2