ID   A549-deltaSTAT1
AC   CVCL_C9AT
SY   A549 STAT1-/-
DR   Wikidata; Q123030360
RX   PubMed=29321309;
RX   PubMed=35421191;
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 11362; STAT1.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0023 ! A-549
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 30-01-24; Version: 2
//
RX   PubMed=29321309; DOI=10.1128/JVI.02021-17;
RA   Aydillo-Gomez T.A., Ayllon-Barasoain J., Pavlisin A., Martinez-Romero C.,
RA   Tripathi S., Mena I., Moreira-Soto A., Vicente-Santos A.,
RA   Corrales-Aguilar E., Schwemmle M., Garcia-Sastre A.;
RT   "Specific mutations in the PB2 protein of influenza A virus compensate
RT   for the lack of efficient interferon antagonism of the NS1 protein of
RT   bat influenza A-like viruses.";
RL   J. Virol. 92:e02021.17.1-e02021.17.18(2018).
//
RX   PubMed=35421191; DOI=10.1371/journal.ppat.1010464;
RA   Danziger O., Patel R.S., DeGrace E.J., Rosen M.R., Rosenberg B.R.;
RT   "Inducible CRISPR activation screen for interferon-stimulated genes
RT   identifies OAS1 as a SARS-CoV-2 restriction factor.";
RL   PLoS Pathog. 18:E1010464-E1010464(2022).
//