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Cellosaurus SUM159R (CVCL_C9AN)

[Text version]
Cell line name SUM159R
Synonyms SUM-159PT(R)
Accession CVCL_C9AN
Resource Identification Initiative To cite this cell line use: SUM159R (RRID:CVCL_C9AN)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Selected for resistance to: ChEBI; CHEBI_137113; JQ1.
Omics: Phenotyping; CRISPR screening.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Leu (c.3140A>T); ClinVar=VCV000013653; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val157_Arg158insLeu (c.472_473ins3); Zygosity=Unspecified (from parent cell line).
Disease Breast pleomorphic carcinoma (NCIt: C5161)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5423 (SUM159PT)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
Publications

PubMed=26735014; DOI=10.1038/nature16508; PMCID=PMC4854653
Shao-Kun Shu, Charles Y. Lin, Hou-Sheng Hansen He, Robert M. Witwicki, Doris Priscilla Tabassum, Justin M. Roberts, Michalina Janiszewska, Sung Jin Huh, Yi Liang, Jeremy Ryan, Ernest Doherty ...Show all 39 authors... , Hisham Mohammed, Hao Guo, Daniel G. Stover, Muhammad B. Ekram, Jonathan Brown, Clive D'Santos, Ian Elliott Krop, Deborah Dillon, Michael R. McKeown, Christopher Ott, Jun Qi, Min Ni, Prakash K. Rao, Melissa Duarte, Shwu-Yuan Wu, Cheng-Ming Chiang, Lars Anders, Richard Allen Young, Eric Winer, Anthony George Letai, William T. Barry, Jason S. Carroll, Henry Long, Myles A. Brown, Xiao-Le Shirley Liu, Clifford A. Meyer, James E. Bradner, Kornelia Polyak; Show fewer authors
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.
Nature 529:413-417(2016)

PubMed=32416067; DOI=10.1016/j.molcel.2020.04.027; PMCID=PMC7306005
Shao-Kun Shu, Hua-Jun Wu, Jennifer Y. Ge, Rhamy Zeid, Isaac S. Harris, Bojana Jovanovic, Katherine Murphy, Bin-Bin Wang, Xin-Tao Qiu, Jennifer E. Endress, Jaime Reyes ...Show all 39 authors... , Klothilda Lim, Alba Font-Tello, Sudeepa Syamala, Teng-Fei Xiao, Chandra Sekhar Reddy Chilamakuri, Evangelia K. Papachristou, Clive D'Santos, Jayati Anand, Kunihiko Hinohara, Wei Li, Thomas O. McDonald, Adrienne Luoma, Rebecca J. Modiste, Quang-De Nguyen, Brittany Michel, Paloma Cejas, Cigall Kadoch, Jacob D. Jaffe, Kai W. Wucherpfennig, Jun Qi, Xiao-Le Shirley Liu, Henry Long, Myles A. Brown, Jason S. Carroll, Joan Siefert Brugge, James E. Bradner, Franziska Michor, Kornelia Polyak; Show fewer authors
Synthetic lethal and resistance interactions with BET bromodomain inhibitors in triple-negative breast cancer.
Mol. Cell 78:1096-1113.e8(2020)

Cross-references
CRISP screens repositories BioGRID_ORCS_Cell_line; 1396
Encyclopedic resources Wikidata; Q123033572
Entry history
Entry creation05-Oct-2023
Last entry update10-Apr-2025
Version number4