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Cellosaurus Daoy EZHIP KO (CVCL_C8V5)

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Cell line name Daoy EZHIP KO
Synonyms C67-KO Daoy
Accession CVCL_C8V5
Resource Identification Initiative To cite this cell line use: Daoy EZHIP KO (RRID:CVCL_C8V5)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:33738; EZHIP.
Derived from site: In situ; Brain, posterior fossa; UBERON=UBERON_0008788.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys242Phe (c.725G>T); ClinVar=VCV000376578; Zygosity=Homozygous (from parent cell line).
Disease Medulloblastoma, SHH-activated, TP53-mutant (NCIt: C129442)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1167 (Daoy)
Sex of cell Male
Age at sampling 4Y
Category Cancer cell line
Publications

PubMed=33186520; DOI=10.1016/j.ccell.2020.10.009; PMCID=PMC8455074
Ji-Chang Han, Meng Yu, Yi-Qin Bai, Jian-Zhong Yu, Fei Jin, Chen Li, Rong Zeng, Jing-Hong Peng, Ao Li, Xiao-Min Song, Hao Li ...Show all 13 authors... , Dian-Qing Wu, Lin Li; Show fewer authors
Elevated CXorf67 expression in PFA ependymomas suppresses DNA repair and sensitizes to PARP inhibitors.
Cancer Cell 38:844-856.e7(2020)

Cross-references
Encyclopedic resources Wikidata; Q123031155
Entry history
Entry creation05-Oct-2023
Last entry update19-Dec-2024
Version number3