Cellosaurus cell line CUTO-29 (CVCL

Cellosaurus CUTO-29 (CVCL_C8TC)

Cross-references
Cell line name	CUTO-29
Synonyms	CUTO29; Colorado University Thoracic Oncology 29
Accession	CVCL_C8TC
Resource Identification Initiative	To cite this cell line use: CUTO-29 (RRID:CVCL_C8TC)
Comments	Doubling time: 37 +- 1.3 hours (PubMed=35933914). Omics: Genomics; Whole genome sequencing. Omics: Transcriptomics; RNAseq. Omics: Variations; SNP array analysis. Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=35933914). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=35933914). Gene deletion; HGNC; HGNC:7325; MSH2; Zygosity=Homozygous (PubMed=35933914). Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK; Note=E6A19 v3 fusion (PubMed=35933914). Mutation; HGNC; HGNC:427; ALK; Simple; p.Cys1156Tyr (c.3467G>A); ClinVar=VCV000376340; Zygosity=Heterozygous (PubMed=35933914). Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg680Ter (c.2038C>T); ClinVar=VCV000036572; Zygosity=Heterozygous (PubMed=35933914). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys277Tyr (c.830G>A); ClinVar=VCV000185722; Zygosity=Homozygous (PubMed=35933914).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	54Y
Category	Cancer cell line
Publications	PubMed=35933914; DOI=10.1016/j.lungcan.2022.07.010 Abdulmalik Asaadallah A. Bokhari, Wei-Yun Lai, Anh T. Le, Jonatan L. Gabre, Tzu-Po Chuang, Susanne Fransson, Bengt Bergman, Anna Djos, Nan Chen, Tommy Martinsson, Jimmy Van den Eynden ...Show all 15 authors... , Robert C. Doebele, Ruth Helen Palmer, Bengt Hallberg, Ganesh Umapathy; Show fewer authors Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC. Lung Cancer 171:103-114(2022)
Encyclopedic resources	Wikidata; Q123030994
Gene expression databases	ArrayExpress; E-MTAB-11342
Entry history
Entry creation	05-Oct-2023
Last entry update	10-Apr-2025
Version number	4