ID   CUTO-29
AC   CVCL_C8TC
SY   CUTO29; Colorado University Thoracic Oncology 29
DR   ArrayExpress; E-MTAB-11342
DR   Wikidata; Q123030994
RX   PubMed=35933914;
CC   Doubling time: 37 +- 1.3 hours (PubMed=35933914).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=35933914).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=35933914).
CC   Sequence variation: Gene deletion; HGNC; HGNC:7325; MSH2; Zygosity=Homozygous (PubMed=35933914).
CC   Sequence variation: Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK; Note=E6A19 v3 fusion (PubMed=35933914).
CC   Sequence variation: Mutation; HGNC; HGNC:427; ALK; Simple; p.Cys1156Tyr (c.3467G>A); ClinVar=VCV000376340; Zygosity=Heterozygous (PubMed=35933914).
CC   Sequence variation: Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg680Ter (c.2038C>T); ClinVar=VCV000036572; Zygosity=Heterozygous (PubMed=35933914).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys277Tyr (c.830G>A); ClinVar=VCV000185722; Zygosity=Homozygous (PubMed=35933914).
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   54Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 10-04-25; Version: 4
//
RX   PubMed=35933914; DOI=10.1016/j.lungcan.2022.07.010;
RA   Bokhari A.A.A., Lai W.-Y., Le A.T., Gabre J.L., Chuang T.-P.,
RA   Fransson S., Bergman B., Djos A., Chen N., Martinsson T.,
RA   Van den Eynden J., Doebele R.C., Palmer R.H., Hallberg B., Umapathy G.;
RT   "Novel human-derived EML4-ALK fusion cell lines identify
RT   ribonucleotide reductase RRM2 as a target of activated ALK in
RT   NSCLC.";
RL   Lung Cancer 171:103-114(2022).
//