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Cellosaurus Hep3B-c1 (CVCL_C8Q9)

[Text version]
Cell line name Hep3B-c1
Synonyms Hep3Bc1
Accession CVCL_C8Q9
Resource Identification Initiative To cite this cell line use: Hep3B-c1 (RRID:CVCL_C8Q9)
Comments Population: African American.
Characteristics: Expression of firefly luciferase is under the control of a 68-bp hypoxia response element (HRE) from the human ENO1 gene inserted upstream of a basal SV40 promoter. Expression of renilla luciferase is constitutive as it is driven by the SV40 promoter (PubMed=19020076).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P27652; Renilla reniformis renilla-type luciferase.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:903; AXIN1; Simple; p.Arg146Ter (c.436C>T); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Ser576Ter (c.1727C>G); Zygosity=Homozygous (from parent cell line).
Disease Childhood hepatocellular carcinoma (NCIt: C7955)
Pediatric hepatocellular carcinoma (ORDO: Orphanet_33402)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0326 (Hep 3B2.1-7)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
Publications

PubMed=19020076; DOI=10.1073/pnas.0809763105; PMCID=PMC2604945
Hua-Feng Zhang, David Z. Qian, Yee Sun Tan, KangAe Lee, Ping Gao, Yun-Zhao R. Ren, Sergio Rey, Hans Hammers, Daniel Chang, Roberto Pili, Chi V. Dang ...Show all 13 authors... , Jun O. Liu, Gregg Leonard Semenza; Show fewer authors
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.
Proc. Natl. Acad. Sci. U.S.A. 105:19579-19586(2008)

Cross-references
Anatomy/cell type resources BTO; BTO_0006479
Encyclopedic resources Wikidata; Q123031636
Entry history
Entry creation05-Oct-2023
Last entry update14-Aug-2025
Version number5