ID   Hep3B-c1
SY   Hep3Bc1
DR   BTO; BTO:0006479
DR   Wikidata; Q123031636
RX   PubMed=19020076;
CC   Population: African American.
CC   Characteristics: Expression of firefly luciferase is under the control of a 68-bp hypoxia response element (HRE) from the human ENO1 gene inserted upstream of a basal SV40 promoter. Expression of renilla luciferase is constitutive as it is driven by the SV40 promoter (PubMed=19020076).
CC   Sequence variation: Mutation; HGNC; 903; AXIN1; Simple; p.Arg146Ter (c.436C>T); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Ser576Ter (c.1727C>G); Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; P27652; Renilla-type luciferase.
CC   Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7955; Childhood hepatocellular carcinoma
DI   ORDO; Orphanet_33402; Pediatric hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0326 ! Hep 3B2.1-7
SX   Male
AG   8Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 30-01-24; Version: 2
RX   PubMed=19020076; DOI=10.1073/pnas.0809763105;
RA   Zhang H.-F., Qian D.Z., Tan Y.S., Lee K., Gao P., Ren Y.-Z.R., Rey S.,
RA   Hammers H., Chang D., Pili R., Dang C.V., Liu J.O., Semenza G.L.;
RT   "Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and
RT   block tumor growth.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:19579-19586(2008).